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Reconsolidation: The effects of dopamine receptors on spreading depression in rat neocortical tissues

von Dr. Anna Maria Haarmann

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[1.] Amh/Fragment 007 01 - Diskussion
Zuletzt bearbeitet: 2014-05-06 21:07:04 WiseWoman
Amh, Fragment, Gesichtet, SMWFragment, Schutzlevel sysop, Somjen 2001, Verschleierung

Typus
Verschleierung
Bearbeiter
Graf Isolan
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 7, Zeilen: 1-13
Quelle: Somjen 2001
Seite(n): 1070, Zeilen: right col. 8-25
[An exact and complete balance sheet of all ingredients displaced during SD is yet to be completed, however, so much larger than that of the interstitial] compartment that neurons need to give up but a fraction of the K+ they contain to achieve a many fold rise in [K+]o. Calculations based on the simultaneously recorded levels of [Na+]o and [K+]o and the known fractional volume of the interstitial space in hippocampal tissue indicate that a much reduced but still substantial trans-membrane potassium concentration gradient remains standing during SD.

The unusual magnitude of the changes in extracellular ion concentrations created the impression that intra- and extracellular ion concentrations equilibrate during SD, and this idea was bolstered by the nearly complete depolarization of neurons during SD. The volume of the cytosol is, however, so much larger than that of the interstitial space that cells need to give up but a fraction of the K+ they contain to achieve a many fold rise in [K+]o. Calculations based on the simultaneously recorded levels of [Na+]o and [K+]o and the known fractional volume of the interstitial space in hippocampus indicate that a much reduced but still substantial transmembrane K+ concentration gradient remains standing during SD.

An exact and complete balance sheet of all ingredients displaced during SD is yet to be completed, however.

The unusual magnitude of the changes in extracellular ion concentrations created the impression that intra- and extracellular ion concentrations equilibrate during SD, and this idea was bolstered by the nearly complete depolarization of neurons during SD (57, 137, 391; see sect. IIH). The volume of the cytosol is, however, so much larger than that of the interstitial space that cells need to give up but a fraction of the K1 they contain to achieve a manyfold rise in [K+]o. Calculations based on the simultaneously recorded levels of [Na+]o and [K+]o and the known fractional volume of the interstitial space in hippocampus indicate that a much reduced but still substantial transmembrane K+ concentration gradient remains standing during HSD (267) (Figs. 4A and 7D).

Anmerkungen

Nothing is marked as a citation.

Amh uses the same passage of text twice on the same page. The first time around there are still some slight changes to the original text ("potassium" instead of "K+"). The second time the match is exact

Sichter
(Graf Isolan) Schumann

[2.] Amh/Fragment 007 14 - Diskussion
Zuletzt bearbeitet: 2014-05-07 18:43:40 Schumann
Amh, Fragment, Gesichtet, SMWFragment, Schutzlevel sysop, Sheikh 2009, Verschleierung

Typus
Verschleierung
Bearbeiter
Hindemith
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 7, Zeilen: 14-19
Quelle: Sheikh 2009
Seite(n): 7, Zeilen: 10-15
No explanation of the propagation of SD has been suggested that accounts for all the facts presently proven. The hypothesis that gained wide acceptance is that the propagation of SD probably involves the release of different chemical mediators, most likely K+ and glutamate into the interstitial fluid. Given the widespread potential signalling capacities of Ca2+ waves, observations of the interactions between astrocytes and neurons in cell culture have suggested that Ca2+ waves may also play a role in SD propagation. No explanation of the propagation of SD has been suggested that accounts for all the facts presently proven. The hypothesis that gained wide acceptance is that the spread of SD probably involves the release and diffusion of the chemical mediators, most likely K+ and glutamate into the interstitial fluid. Given the widespread potential signalling capacities of Ca2+ waves, observations of the interactions between astrocytes and neurons in cell culture have suggested that Ca2+ waves play a role in SD initiation and propagation (Gorji 2001).
Anmerkungen

The source is not mentioned.

Note that the almost identical text can be found in the source Gorji (2001): Amh/Dublette/Fragment_007_14

Sichter
(Hindemith) Schumann


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