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Typus
Verschleierung
Bearbeiter
Graf Isolan
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 5, Zeilen: 16-24
Quelle: Somjen 2001
Seite(n): 1066-1067, Zeilen: 1066:right col. 41-43 - 1067:left col. 1-12
The first paper on SD, titled "Spreading depression of activity in the cerebral cortex" appeared in 1944, written by a young Brazilian investigator, Aristides Leão, working at the Harvard laboratory. Leão wanted to study the electrocorticogram (ECoG) of experimental epilepsy in anesthetized rabbits, but he was distracted from his original goal by an unexpected flattening of the ongoing normal bioelectrical activity that took the place of the anticipated epileptiform field potentials.The silencing of the ECoG trace crept slowly over the cortex, from one recording electrode pair resting on the cortical surface to the one beside it. According to Leão, SD and propagating focal seizures were related phenomena, generated by the same cellular elements, an inference later supported by others. [page 1066]

The first, seminal paper on SD, titled “Spreading depression of activity in the cerebral cortex” (213) appeared in 1944, written by a young and unknown Brazilian inves-

[page 1067]

tigator, Aristides Leão, working at the Harvard laboratory of R. S. Morison. Leão wanted to study the cortical electrogram (ECoG) of experimental epilepsy in anesthetized rabbits, but he was distracted from his original goal by an unexpected silencing of the ongoing normal electrical activity that took the place of the anticipated seizure (Fig. 1). The flattening of the ECoG trace crept slowly over the cortex, from one recording electrode pair resting on the cortical surface to the one beside it. According to Leão, SD and propagating focal seizures were related phenomena, generated by the same cellular elements (213), an inference later supported by others (e.g., Ref. 428).


213. LEÃO AAP. Spreading depression of activity in the cerebral cortex. J Neurophysiol 7: 359–390, 1944.

428. VAN HARREVELD A AND STAMM JS. Spreading cortical convulsions and depressions. J Neurophysiol 16: 352–366, 1953.

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