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Typus
Verschleierung
Bearbeiter
Graf Isolan
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 9, Zeilen: 26-31
Quelle: Eikermann-Haerter and Moskowitz 2008
Seite(n): 297, Zeilen: left col. 26-38
Recent investigations provide early insights into mechanisms that lead to trigeminovascular activation. SD is the first endogenous event identified upstream to trigeminovascular activation that appears to be noxious in experimental models. Neocortical SD, originally described by Leão. The slow spread of SD at 3–5 mm/min matches the propagation velocity of wave fronts in the Belousov–Zhabotinsky reaction, that is, a thermodynamic chemical reaction that shows the properties of a nonlinear chemical oscillator even in a Petri dish. Recent studies provide early insights into endogenous mechanisms that lead to trigeminovascular activation. CSD is the first endogenous event identified upstream to trigeminovascular activation that appears to be noxious in experimental models. CSD, originally described by Leão [73], is an intense depolarization of neuronal and glial membranes accompanied by a massive disruption of ionic gradients and loss of membrane resistance [5]. The slow spread of CSD at 3–5 mm/min matches the propagation velocity of wave fronts in the Belousov–Zhabotinsky reaction, that is, a thermodynamic chemical reaction that shows the properties of a nonlinear chemical oscillator even in a Petri dish [74].

3 Eikermann-Haerter K, Moskowitz MA. Pathophsyiology of aura. In: Silberstein BR, editor. Wolff’s headache and other head pain. 2007. pp. 121–132.
This chapter gives a comprehensive overview on pathophysiology of migraine aura and summarizes important findings in both basic and clinical research.

73 Leão AAP. Spreading depression of activity in cerebral cortex. J Neurophysiol 1944; 7:359–390.

74 Biosa G, Bastianoni S, Rustici M. Chemical waves. Chemistry 2006; 12:3430–3437.

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