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Typus
Verschleierung
Bearbeiter
DerFurz, Hindemith
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 24, Zeilen: 3-20
Quelle: Noble 2003
Seite(n): 113, Zeilen: l.col: 44ff
A huge amount of data suggests that dopaminergic activation is a primary pathophysiologic component in certain subtypes of migraine (Peroutka, 1997). This has led to an examination of D2 variants in this disorder. In one study the NcoI D2 C to T polymorphism located in exon 6 was assessed in individuals having migraine with aura and without aura (Peroutka, 1997). Individuals having migraine with aura had a significantly higher frequency of the D2 C allele than did control or migraine without aura individuals. No D2 C allele frequency difference was found, however, between the latter two groups. The association of NcoI DRD2 variants in comorbid migraine with aura, anxiety and depression was also reported (Peroutka, 1998). The D2 C allele frequency was significantly higher in individuals with migraine without aura, anxiety disorders or major depression than in individuals who had none of these disorders. Another group (Del Zompo et al.,1998) utilized the Transmission Disequilibrium Test and the dinucleotide repeat alleles within intron 2 of the D2 gene to test for association with patients affected by migraine without aura. Although no difference was observed in D2 repeat allelic distribution in the overall sample, allelic distribution differed significantly in a subgroup of dopaminergic migraineurs. Another D2 gene polymorphism (promoter -141C Ins/Del), however, was not found to be associated with migraine (Maude et al., 2001). Furthermore, a significant and independent association was found of SNPs in the insulin receptor and the D2 SNP93 with migraine subjects (McCarthy et al., 2001). A growing body of data suggests that dopaminergic activation is a primary pathophysiologic component in certain subtypes of migraine [Peroutka, 1997]. This has led to an examination of DRD2 variants in this disorder. In one study [Peroutka et al., 1997], the NcoI DRD2 C to T polymorphism located in exon 6 was assessed in individuals having migraine with aura (MWA) and without aura (MO). Individuals having MWA had a significantly higher frequency of the DRD2 C allele than did controls or MO individuals. No DRD2 C allele frequency difference was found, however, between the latter two groups. The same laboratory [Peroutka et al., 1998] also studied the association of NcoI DRD2 variants in comorbid migraine with aura, anxiety and depression. The DRD2 C allele frequency was significantly higher in individuals with MWA, anxiety disorders or major depression than in individuals who had none of these disorders. Another group [Del Zompo et al., 1998] utilized the Transmission Disequilibrium Test and the dinucleotide repeat alleles within intron 2 of the DRD2 gene to test for association with patients affected by migraine without aura. Although no difference was observed in DRD2 repeat allelic distribution in the overall sample, allelic distribution differed significantly in a subgroup of dopaminergic migraineurs. Another DRD2 gene polymorphism (promoter 141C Ins/Del), however, was not found to be associated with migraine [Maude et al., 2001]. Finally, in a large study of subjects with typical migraine and controls, a significant and independent association was found of SNPs in the insulin receptor and the DRD2 SNP93 (NcoI polymorphism) with migraine subjects [McCarthy et al., 2001].
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Sichter
(Hindemith) Schumann

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