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Graf Isolan
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Untersuchte Arbeit:
Seite: 3, Zeilen: 2-9
Quelle: Lou 2008
Seite(n): 3, Zeilen: 14-21
Botstein et al. (1980) proposed the concept using RFLP’s as the markers to construct a genetic map. Later, genetic maps were constructed using denser microsatellites (Murray et al., 1994; Dib et al., 1996). SNPs, which usually contain two alleles, have drawn significant attention as markers for genetic disease-mapping studies due to their high abundance across the human genome (Kruglyak, 1997; Sachidanandam et al., 2001). It was estimated

that there are around 7.1 million SNPs with a minimal allele frequency of at least 0.05 in the human population (Kruglyak and Nickerson, 2001).


Dib, C., Fauré, S., Fizames, C., Samson, D., Drouot, N., Vignal, A., Millasseau, P., Marc, S., Hazan, J., Seboun, E. & others (1996) A comprehensive genetic map of the human genome based on 5,264 microsatellites. Nature, 380(6570): 152–154.

Kruglyak, L. (1997) The use of a genetic map of biallelic markers in linkage studies. Nat Genet, 17(1): 21–24.

Kruglyak, L. & Nickerson, D. A. (2001) Variation is the spice of life. Nat Genet, 27(3): 234–236.

Murray, J. C., Buetow, K. H., Weber, J. L., Ludwigsen, S., Scherpbier-Heddema, T., Manion, F., Quillen, J., Sheffield, V. C., Sunden, S., Duyk, G. M. & others (1994) A comprehensive human linkage map with centimorgan density. Science, 265(5181): 2049–2054.

Sachidanandam, R., Weissman, D., Schmidt, S. C., Kakol, J. M., Stein, L. D., Marth, G., Sherry, S., Mullikin, J. C., Mortimore, B. J.,Willey, D. L. & others (2001) A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms. Nature, 409(6822): 928–933.

Botstein et al. (Botstein et al. 1980) proposed the concept using RFLP’s as the markers to construct a genetic map. Later, denser microsatellites were used to construct genetic maps (Murray et al. 1994; Dib et al. 1996). SNPs, which usually contain two alleles, have become the standard polymorphisms nowadays for higher resolution genetic disease-mapping due to their abundance throughout the human genome (Kruglyak 1997; Sachidanandam et al. 2001). It was estimated that there are around 7.1 million SNPs with a minimal allele frequency of at least 0.05 in the human population (Kruglyak & Nickerson 2001).

Dib, C., S. Faure, C. Fizames, D. Samson, N. Drouot et al. 1996 A comprehensive genetic map of the human genome based on 5,264 microsatellites. Nature 380: 152-154.

Kruglyak, L., 1997 The use of a genetic map of biallelic markers in linkage studies. Nature Genetics 17: 21-24.

Kruglyak, L., and D. A. Nickerson, 2001 Variation is the spice of life. Nature Genetics 27: 234-236.

Murray, J. C., K. H. Buetow, J. L. Weber, S. Ludwigsen, T. Scherpbierheddema et al. 1994 A Comprehensive Human Linkage with Centimorgan Density. Science 265: 2049-2054.

Sachidanandam, R., D. Weissman, S. C. Schmidt, J. M. Kakol, L. D. Stein et al. 2001 A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms. Nature 409: 928-933.

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