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Bearbeiter
Graf Isolan
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Untersuchte Arbeit:
Seite: 11, Zeilen: 24-28
Quelle: Rudolph et al 2006
Seite(n): 420, Zeilen: right col. 27-32, 39-45
Both classes of MHC molecules are heterodimers with similar architectures and are composed of three domains, one α-helix/β-sheet superdomain that forms the peptide-binding site and two immunoglobulin (Ig)-like domains (Fig.1) (Bjorkman et al., 1987b; Brown et al., 1993; Fremont et al., 1996; Madden et al., 1993; Matsumura et al., 1992; Stern and Wiley, 1994). The overall architecture is the same in both MHC classes, where a seven-[stranded β-sheet represents the floor of the peptide-binding groove, and the sides are formed by two long α-helices, that straddle the β-sheet.]

Bjorkman, P.J., Saper, M.A., Samraoui, B., Bennett, W.S., Strominger, J.L., and Wiley, D.C. (1987b). Structure of the human class I histocompatibility antigen, HLA-A2. Nature 329, 506-512.

Brown, J.H., Jardetzky, T.S., Gorga, J.C., Stern, L.J., Urban, R.G., Strominger, J.L., and Wiley, D.C. (1993). Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1. Nature 364, 33-39.

Fremont, D.H., Hendrickson, W.A., Marrack, P., and Kappler, J. (1996). Structures of an MHC class II molecule with covalently bound single peptides. Science 272, 1001-1004.

Madden, D.R., Garboczi, D.N., and Wiley, D.C. (1993). The antigenic identity of peptide-MHC complexes: a comparison of the conformations of five viral peptides presented by HLA-A2. Cell 75, 693-708.

Matsumura, M., Fremont, D.H., Peterson, P.A., and Wilson, I.A. (1992). Emerging principles for the recognition of peptide antigens by MHC class I molecules. Science 257, 927-934.

Stern, L.J., and Wiley, D.C. (1994). Antigenic peptide binding by class I and class II histocompatibility proteins. Structure 2, 245-251.

Both classes of MHC are heterodimers with similar architectures and are composed of three domains, one α-helix/β-sheet (αβ) superdomain that forms the peptide-binding site and two Ig-like domains. [...] Notwithstanding, in both MHC classes, the overall architecture is the same where a seven-stranded β-sheet represents the floor of the binding groove, and the sides are formed by two long α-helices (or continuous α-helical segments in the α2- or β1-helices) that straddle the [β-sheet (Figure 2a,b).]

43. Madden DR, Garboczi DN, Wiley DC. 1993. The antigenic identity of peptide-MHC complexes: a comparison of the conformations of five viral peptides presented by HLAA2. Cell 75:693–708

44. Stern LJ,Wiley DC. 1994. Antigenic peptide binding by class I and class II histocompatibility proteins. Structure 2:245–51

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