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| Untersuchte Arbeit: Seite: 15, Zeilen: 1-6 |
Quelle: Rudolph et al 2006 Seite(n): 425, Zeilen: left col. 10-16 |
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| 1.1.1.2 The T cell receptor
TcRs are cell surface heterodimers consisting of either disulfide-linked α and β or γ and δ -chains (Brenner et al., 1986; Chien et al., 1987; Hedrick et al., 1984; Koning et al., 1987; Saito et al., 1984; Winoto and Baltimore, 1989; Yanagi et al., 1984). Sequence analyses correctly predicted that TcRs would share a domain organization and binding mode similar to those of antibody Fab fragments (Davis and Bjorkman, 1988). Brenner, M.B., McLean, J., Dialynas, D.P., Strominger, J.L., Smith, J.A., Owen, F.L., Seidman, J.G., Ip, S., Rosen, F., and Krangel, M.S. (1986). Identification of a putative second T-cell receptor. Nature 322, 145-149. Chien, Y.H., Iwashima, M., Wettstein, D.A., Kaplan, K.B., Elliott, J.F., Born, W., and Davis, M.M. (1987). T-cell receptor delta gene rearrangements in early thymocytes. Nature 330, 722-727. Davis, M.M., and Bjorkman, P.J. (1988). T-cell antigen receptor genes and T-cell recognition. Nature 334, 395-402. Hedrick, S.M., Cohen, D.I., Nielsen, E.A., and Davis, M.M. (1984). Isolation of cDNA clones encoding T cell-specific membrane-associated proteins. Nature 308, 149-153. Koning, F., Stingl, G., Yokoyama, W.M., Yamada, H., Maloy, W.L., Tschachler, E., Shevach, E.M., and Coligan, J.E. (1987). Identification of a T3-associated gamma delta T cell receptor on Thy-1+ dendritic epidermal Cell lines. Science 236, 834-837. Saito, H., Kranz, D.M., Takagaki, Y., Hayday, A.C., Eisen, H.N., and Tonegawa, S. (1984). A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes. Nature 312, 36-40. Winoto, A., and Baltimore, D. (1989). Separate lineages of T cells expressing the alpha beta and gamma delta receptors. Nature 338, 430-432. Yanagi, Y., Yoshikai, Y., Leggett, K., Clark, S.P., Aleksander, I., and Mak, T.W. (1984). A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains. Nature 308, 145-149. |
αβ and γδ TCRs
TCRs are cell surface heterodimers consisting of either disulfide-linked α- and β- or γ- and δ-chains. Sequence analyses correctly predicted that TCRs would share a domain organization and binding mode similar to those of antibody Fab fragments (69, 70). 69. Claverie JM, Prochnicka-Chalufour A, Bougueleret L. 1989. Implications of a Fab-like structure for the T-cell receptor. Immunol. Today 10:10–14 70. Davis MM, Bjorkman PJ. 1988. T-cell antigen receptor genes and T-cell recognition. Nature 334:395–402 |
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