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Typus
Verschleierung
Bearbeiter
Graf Isolan
Gesichtet
No.png
Untersuchte Arbeit:
Seite: 16, Zeilen: 1-7
Quelle: Rudolph et al 2006
Seite(n): 437, Zeilen: left col. 15-30
[This comparison disclosed a] functional hotspot between the CDR3 loops in the 2C TcR that finely discriminated between side chains and conformations of centrally located peptide residues through increased complementarity and additional hydrogen bonds. In the A6 system, altered peptide ligands (APLs) induced only subtle conformational changes in the TcR. In both the 2C and A6 systems, conformational changes are restricted mainly to the CDR3 loop regions, and the largest conformational differences were observed when comparing free versus bound TcRs (Rudolph and Wilson, 2002).

Rudolph, M.G., and Wilson, I.A. (2002). The specificity of TCR/pMHC interaction. Curr Opin Immunol 14, 52-65.

This comparison disclosed a functional hotspot between the CDR3 loops in the 2C TCR that finely discriminated between side chains and conformations of centrally located peptide residues through increased complementarity and additional hydrogen bonds. In the A6 system (13, 14), altered peptide ligands (APLs), i.e., peptides of slightly different sequence than the natural ligand, induced only subtle conformational changes in the TCR (Figure 7b). In both the 2C and A6 systems, conformational changes are restricted mainly to the CDR3 loop regions, and the largest conformational differences were observed when comparing free versus bound TCR (36).

13. Ding YH, Smith KJ, Garboczi DN, Utz U, Biddison WE,Wiley DC. 1998. Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids. Immunity 8:403–11

14. Ding YH, Baker BM, Garboczi DN, Biddison WE, Wiley DC. 1999. Four A6-TCR/peptide/HLA-A2 structures that generate very different T cell signals are nearly identical. Immunity 11:45–56

36. Rudolph MG,Wilson IA. 2002. The specificity of TCR/pMHC interaction. Curr. Opin. Immunol. 14:52–65

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