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Graf Isolan
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Untersuchte Arbeit:
Seite: 29, Zeilen: 14-19
Quelle: DeNucci et al 2009
Seite(n): 1, 2, Zeilen: 1:7-10; 2:7-8
The continuous recirculation of naïve T cells and their subsequent migration to tissues following activation is crucial for maintaining protective immunity against invading pathogens. The preferential targeting of effector and memory T cells to tissues is instructed during priming and mediated by cell surface expressed adhesion receptors such as integrins.

Integrins are αβ heterodimeric cell surface adhesion molecules that mediate cell-extracellular matrix (ECM) and cell-cell interactions (Pribila et al., 2004), which are essential for T cell recirculation, migration into inflammatory sites and for a specific and effective immune response against foreign pathogens (Hynes, 2002; Shimizu et al., 1999).


Hynes, R.O. (2002). Integrins: bidirectional, allosteric signaling machines. Cell 110, 673-687.

Pribila, J.T., Quale, A.C., Mueller, K.L., and Shimizu, Y. (2004). Integrins and T cell-mediated immunity. Annu Rev Immunol 22, 157-180.

Shimizu, Y., Rose, D.M., and Ginsberg, M.H. (1999). Integrins in the immune system. Adv Immunol 72, 325-380.

[Page 1 (Author Manuscript)]

The continuous recirculation of naïve T cells and their subsequent migration to tissue following activation is crucial for maintaining protective immunity against invading pathogens. The preferential targeting of effector and memory T cells to tissue is instructed during priming and mediated by cell surface expressed adhesion receptors such as integrins.

[Page 2 (Author Manuscript)]

Integrins are widely expressed cell surface adhesion molecules that mediate cell-extracellular matrix (ECM) and cell-cell interactions.2


2. Pribila JT, Quale AC, Mueller KL, Shimizu Y. Integrins and T cell-mediated immunity. Annu Rev Immunol 2004;22:157–80. [PubMed: 15032577]

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