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Typus
Verschleierung
Bearbeiter
Graf Isolan
Gesichtet
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Untersuchte Arbeit:
Seite: 30, Zeilen: 1-10
Quelle: DeNucci et al 2009
Seite(n): 2, 9, Zeilen: 2:24-31; 9:4-6
The interaction of αLβ2 with ICAM-1 is important for T cell entry into pLN and for T cell interactions with APCs. The α4β1 ligand VCAM-1 is expressed at low levels throughout the vasculature, but becomes upregulated on a wide array of tissue during inflammation (Henninger et al., 1997). MAdCAM-1, the major ligand for α4β7 is preferentially expressed at steady state in the mLN and Peyer’s patches, where it promotes entry of naïve T cells into these sites through a high affinity interaction (Berlin et al., 1993; Erle et al., 1994; von Andrian and Mackay, 2000). Both VCAM-1 and ICAM-1 are also expressed on the vasculature of the inflamed brain. In particular, VCAM-1 is known to promotes [sic] T cell entry through its interaction with α4β1 expressed on activated T cells (Engelhardt and Ransohoff, 2005).

Berlin, C., Berg, E.L., Briskin, M.J., Andrew, D.P., Kilshaw, P.J., Holzmann, B., Weissman, I.L., Hamann, A., and Butcher, E.C. (1993). Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. Cell 74, 185-195.

Engelhardt, B., and Ransohoff, R.M. (2005). The ins and outs of T-lymphocyte trafficking to the CNS: anatomical sites and molecular mechanisms. Trends Immunol 26, 485-495.

Erle, D.J., Briskin, M.J., Butcher, E.C., Garcia-Pardo, A., Lazarovits, A.I., and Tidswell, M. 1994). Expression and function of the MAdCAM-1 receptor, integrin alpha 4 beta 7, on human leukocytes. J Immunol 153, 517-528.

Henninger, D.D., Panes, J., Eppihimer, M., Russell, J., Gerritsen, M., Anderson, D.C., and Granger, D.N. (1997). Cytokine-induced VCAM-1 and ICAM-1 expression in different organs of the mouse. J Immunol 158, 1825-1832.

von Andrian, U.H., and Mackay, C.R. (2000). T-cell function and migration. Two sides of the same coin. N Engl J Med 343, 1020-1034.

[Page 2 (Author Manuscript)]

The interaction of αLβ2 with ICAM-1 is important for T cell entry into pLN and T cell interactions with antigen-presenting cells (APCs). The α4β1 ligand VCAM-1 is expressed at low levels throughout the vasculature, but becomes upregulated on a wide array of tissue during inflammation.7 α4β7 is also reported to bind with low affinity to VCAM-1 in vitro and under some circumstances may play a role in pLN entry.8–10 MAdCAM-1, the major ligand for α4β7 is preferentially expressed at steady state in the mLN and PP, where it promotes entry of naïve T cells into these sites through a high affinity interaction.11–13

[Page 9 (Author Manuscript)]

Both VCAM-1 and ICAM-1 are expressed on the vasculature of the inflamed brain. In particular, VCAM-1 is known to promote T cell entry through its interaction with α4β1 expressed on activated T cells.125


7. Henninger DD, Panes J, Eppihimer M, Russell J, Gerritsen M, Anderson DC, Granger DN. Cytokine-induced VCAM-1 and ICAM-1 expression in different organs of the mouse. J Immunol 1997;158:1825–32. [PubMed: 9029122]

8. Ruegg C, Postigo AA, Sikorski EE, Butcher EC, Pytela R, Erle DJ. Role of integrin α4β7/α4βP in lymphocyte adherence to fibronectin and VCAM-1 and in homotypic cell clustering. J Cell Biol 1992;117:179–89. [PubMed: 1372909]

9. Day ES, Osborn L, Whitty A. Effect of divalent cations on the affinity and selectivity of α4 integrins towards the integrin ligands vascular cell adhesion molecule-1 and mucosal addressin cell adhesion molecule-1: Ca2+ activation of integrin α4β1 confers a distinct ligand specificity. Cell Commun Adhes 2002;9:205–19. [PubMed: 12699089]

10. Berlin-Rufenach C, Otto F, Mathies M, Westermann J, Owen MJ, Hamann A, Hogg N. Lymphocyte migration in lymphocyte function-associated antigen (LFA)-1-deficient mice. J Exp Med 1999;189:1467–78. [PubMed: 10224287]

11. Erle DJ, Briskin MJ, Butcher EC, Garcia-Pardo A, Lazarovits AI, Tidswell M. Expression and function of the MAdCAM-1 receptor, integrin α4β7, on human leukocytes. J Immunol 1994;153:517–28. [PubMed: 7517418]

12. Berlin C, Berg EL, Briskin MJ, Andrew DP, Kilshaw PJ, Holzmann B, Weissman IL, Hamann A, Butcher EC. α4β7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. Cell 1993;74:185–95. [PubMed: 7687523]

13. von Andrian UH, Mackay CR. T-cell function and migration. Two sides of the same coin. N Engl J Med 2000;343:1020–34. [PubMed: 11018170]

125. Engelhardt B, Ransohoff RM. The ins and outs of T-lymphocyte trafficking to the CNS: anatomical sites and molecular mechanisms. Trends Immunol 2005;26:485–95. [PubMed: 16039904]

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