Fandom

VroniPlag Wiki

Analyse:Ftp/Fragment 018 14

31.377Seiten in
diesem Wiki
Seite hinzufügen
Diskussion0

Störung durch Adblocker erkannt!


Wikia ist eine gebührenfreie Seite, die sich durch Werbung finanziert. Benutzer, die Adblocker einsetzen, haben eine modifizierte Ansicht der Seite.

Wikia ist nicht verfügbar, wenn du weitere Modifikationen in dem Adblocker-Programm gemacht hast. Wenn du sie entfernst, dann wird die Seite ohne Probleme geladen.


Typus
Verschleierung
Bearbeiter
SleepyHollow02
Gesichtet
No.png
Untersuchte Arbeit:
Seite: 18, Zeilen: 14 ff.
Quelle: Katzaki 2009
Seite(n): 21 f, Zeilen: 21: 9 ff.; 22: 1 ff.
1.3.3 Application to detect the prevalence of mosaicism

Even though the effect of mosaicism on embryonic development and pregnancy outcome is not entirely clear, mosaic chromosomal imbalances have been shown to affect the development of in vitro-generated preimplantation embryos. [56] However, the detection of mosaicism in only 5% of aneuploid spontaneous miscarriages between 6-20 weeks gestation [57] and in only 12% of viable pregnancies screened by chorionic villus sampling (CVS) [58] [59] indicates that the incidence of mosaicism decreases through the first and second trimesters of pregnancy and is even rarer in live births. This dramatic reduction in mosaicism from the early stages of embryonic development through the late stages of clinically established pregnancies suggests that there is significant selection against mosaicism. Nevertheless, detecting low-level mosaicism for clinically significant chromosome abnormalities remained a pressing diagnostic challenge for conventional cytogenetic testing until the advent of aCGH. The first systematic study of mosaicism in a large cohort identified mosaicism in as [little as 3% of the cells on the basis of metaphase counts. [60] ]


56. Bielanska, M., S.L. Tan, and A. Ao, Chromosomal mosaicism throughout human preimplantation development in vitro: incidence, type, and relevance to embryo outcome. Hum Reprod, 2002. 17(2): p. 413-9.

57. Hassold, T., Mosaic trisomies in human spontaneous abortions. Hum Genet, 1982. 61(1): p. 31-5.

58. Ledbetter, D.H., et al., Cytogenetic results from the U.S. Collaborative Study on CVS. Prenat Diagn, 1992. 12(5): p. 317-45.

59. Wang, B.B., C.H. Rubin, and J. Williams, 3rd, Mosaicism in chorionic villus sampling: an analysis of incidence and chromosomes involved in 2612 consecutive cases. Prenat Diagn, 1993. 13(3): p. 179-90.

60. Ballif, B.C., et al., Detection of low-level mosaicism by array CGH in routine diagnostic specimens. Am J Med Genet A, 2006. 140(24): p. 2757-67.

Even though the effect of mosaicism on embryonic development and pregnancy outcome is not entirely clear, mosaic chromosomal imbalances have been shown to affect the development of in vitro-generated preimplantation embryos.61 However, the detection of mosaicism in only 5% of aneuploid spontaneous miscarriages between 6-20 weeks gestation62 and in only 12% of viable pregnancies screened by chorionic villus sampling (CVS)63,64 indicates that the incidence of mosaicism decreases through the first and second trimesters of pregnancy and is even rarer in live births. This dramatic reduction in mosaicism from the early stages of embryonic development through the late stages of clinically established pregnancies suggests that there is significant selection against mosaicism. Nevertheless, detecting low-level mosaicism for clinically significant chromosome abnormalities remained a pressing diagnostic challenge for conventional cytogenetic testing until the advent of array-CGH. The first systematic study of mosaicism in a large cohort identified mosaicism in as little as 3% of the cells on the basis of metaphase counts.65

61 Bielanska M, Tan SL, Ao A: Chromosomal mosaicism throughout human preimplantation development in vitro: incidence, type, and relevance to embryo outcome. Hum Reprod 2002; 17: 413-419.

62 Hassold T: Mosaic trisomies in human spontaneous abortions. Hum Genet 1982; 61: 31-35.

63 Ledbetter DH, Zachary JM, Simpson JL et al: Cytogenetic results from the U.S. Collaborative Study on CVS. Prenat Diagn 1992; 12: 317-345.

64 Wang BB, Rubin CH, Williams J, 3rd: Mosaicism in chorionic villus sampling: an analysis of incidence and chromosomes involved in 2612 consecutive cases. Prenat Diagn 1993; 13: 179-190.

65 Ballif BC, Rorem EA, Sundin K et al: Detection of low-level mosaicism by array CGH in routine diagnostic specimens. Am J Med Genet A 2006; 140: 2757-2767.

Anmerkungen

No hint is given that this text comes from another source.

Sichter

Auch bei Fandom

Zufälliges Wiki