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Untersuchte Arbeit:
Seite: 20, Zeilen: 12-18
Quelle: Katzaki 2009
Seite(n): 26, Zeilen: 20 ff.
The application of high-resolution genome analysis in research and clinical laboratories will uncover the genomic basis of many such disorders and will allow for better correlation of the many known CNVs with specific phenotypes. Although this promises to be a very challenging exercise, [79] [80] much work has already been initiated in cancer, neurological and neuropsychological conditions, infectious diseases, and others, suggesting that the clinical utility and applicability of such investigations cannot be too distant.

79. Lupski, J.R., Genomic rearrangements and sporadic disease. Nat Genet, 2007. 39(7 Suppl): p. S43-7.

80. Lupski, J.R., New mutations and intellectual function. Nat Genet, 2010. 42(12): p. 1036-8.

The application of high-resolution genome analysis in research and clinical laboratories will uncover the genomic basis of many such disorders and will allow for better correlation of the many known CNVs with specific phenotypes. Although this promises to be a very challenging exercise,97 much work has already been initiated in cancer, neurological and neuropsychological conditions, infectious diseases, and others, suggesting that the clinical utility and applicability of such investigations cannot be too distant. 25

25 Bejjani BA, Shaffer LG: Clinical utility of contemporary molecular cytogenetics. Annu Rev Genomics Hum Genet 2008; 9: 71-86.

97 Lupski JR: Genomic rearrangements and sporadic disease. Nat Genet 2007; 39: S43-47.

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