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Typus
KomplettPlagiat
Bearbeiter
Graf Isolan
Gesichtet
No.png
Untersuchte Arbeit:
Seite: 2, Zeilen: 14-24
Quelle: Schulte 2000
Seite(n): 8, Zeilen: 1-10
1.2.1 Physiological roles of ROMK channels in the kidney

Intracellular K+ (approximately 145 mM) represents the major portion of total body K+. The K+ concentration in the extracellular fluid ranges from 3.5-5 mM. To maintain a constant serum K+ level, 95% of dietary K+ absorbed from the intestine is excreted through the kidney and the remaining portion is eliminated via the colon (Thier, 1986; Stanton, 1989). Under pathophysiological conditions like chronic renal failure, colonic excretion is increased and can contribute significantly to K+ homeostasis (Martin et al., 1986).

K+ secretion in the kidney is a very complex process depending on flow rate, luminal K+, Na+ and Cl- concentrations, hormones and the acid-base status (Stanton, 1989; Wang, 1995; Giebisch, 1998).


Giebisch, G. (1998)
Renal potassium transport: mechanisms and regulation. Am. J. Physiol. 274, F817-F833

Martin, R. S., Panese, S., Virginillo, M., Gimenez, M., Litardo, M., Arrizurieta, E. and Hayslett, J. P. (1986)
Increased secretion of potassium in the rectum of humans with chronic renal failure. Am. J. Kidney Dis. 8, 105-110

Stanton, B. A. (1989)
Renal potassium transport: morphological and functional adaptations. Am. J. Physiol. 257, R989-R997

Thier, S. O. (1986) Potassium physiology. Am. J. Med. 80, 3-7

'Wang, W. H. (1995) View of K+ secretion through the apical K+ [sic] channel of cortical collecting duct. Kidney Int. 48, 1024-1030

1.2.3 Physiological role in the kidney

Intracellular K+ (approximately 145 mM) represents the major portion of total body K+. The K+ concentration in extracellular fluids ranges from 3.5-5 mM. To maintain a constant serum K+ level, 95% of dietary K+ absorbed from the intestine is excreted through the kidney and the remaining portion is eliminated via the colon (Thier, 1986; Stanton, 1989). Under pathophysiological conditions like chronic renal failure, colonic excretion is increased and can contribute significantly to K+ homeostasis (Martin et al., 1986).

K+ secretion in the kidney is a very complex process depending on flow rate, luminal K+, Na+ and Cl- concentrations, hormones and the acid-base status (Stanton, 1989; Wang, 1995; Giebisch, 1998).


Giebisch, G. (1998) Renal potassium transport: mechanism [sic] and regulation. Am. J. Physiol. 274, F817-F833.

Martin, R. S., Panese, S., Virginillo, M., Gimenez, M., Litardo, M., Arrizurieta, E., and Hayslett, J. P. (1986) Increased secretion of potassium in the rectum of humans with chronic renal failure. Am. J. Kidney Dis. 8, 105-110.

Stanton, B. A. (1989) Renal potassium transport: morphological and functional adaptations. Am. J. Physiol. 257, F989-F997.

Thier, S. O. (1986) Potassium physiology. Am. J. Med. 80, 3-7.

Wang, W.-H. (1995) View of K+ secretion through the apical K channel of the [sic] cortical collecting duct. Kidney Int. 48, 1024-1030.

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