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Typus
ÜbersetzungsPlagiat
Bearbeiter
Hindemith
Gesichtet
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Untersuchte Arbeit:
Seite: 72, Zeilen: 1-14
Quelle: Lozano et al 2007
Seite(n): 726, Zeilen: l.col: 35ff
1.3.6.1. Pelo neonatal

El cabello neonatal es un marcador biológico altamente sensible capaz de informar acerca de la exposición acumulativa a sustancias de abuso durante el último trimestre de vida intrauterina (Klein et al., 2000; Lozano et al., 2007b; Pichini et al., 1996). En el feto, el pelo empieza a crecer durante los últimos 3 o 4 meses del embarazo. Aunque la ventana de detección del meconio es mayor, el pelo neonatal tiene la ventaja de estar disponible durante 4 o 5 meses de la vida postnatal (Bar-Oz et al., 2003). Sin embargo, las muestras de cabello que se pueden obtener en los recién nacidos es a menudo escasa, y la recogida en estos casos especiales puede ser considerada “casi” invasiva. Las muestras de pelo neonatal habitualmente están contaminadas por el líquido amniótico, sin embargo esta contaminación no se debe considerar en el contexto de una contaminación externa ya que se halla en el contexto de una exposición intrauterina a sustancias de abuso.

NEONATAL HAIR

Neonatal hair is a sensitive biological marker that can define cumulative exposure to drugs during the last trimester of intrauterine life.13,73 In the fetus, hair starts growing during the last 3 to 4 months of pregnancy and therefore accounts for exposure occurring in the last trimester. Although the detection window is smaller than for meconium, hair has the advantage of being available for as long as 4 to 5 months of postnatal life.60 However, hair samples that can be obtained in newborns are often sparse, and collection in those particular cases can be considered ‘‘almost’’ invasive. Newborn hair samples are externally contaminated by the amniotic fluid, which not only reaches hair but also the fetus by way of the transdermal route.74 Nevertheless, this contamination should not be considered as external in the context of the diagnosis of intrauterine drug exposure.


13. Pichini S, Altieri I, Zuccaro P, et al. Drugs monitoring in non-conventional biological fluids and matrices. Clin Pharmacokinet. 1996;130:211–228

60. Bar-Oz B, Klein J, Karaskov T, et al. Comparison of meconium and neonatal hair analysis for detection of gestational exposure to drugs of abuse. Arch Dis Child Fetal Neonatal Ed. 2003;88:F98–F100.

73. Klein J, Karaskov T, Koren G. Clinical applications of hair testing for drugs of abuse: the Canadian experience. Forensic Sci Int. 2003;10:281–288.

74. Bailey B, Klein J, Koren G. Noninvasive methods for drug measurement in pediatrics. Pediatr Clin North Am. 1997;44:15–26.

Anmerkungen

The source is mentioned in the beginning together with two other references. Not clear to the reader is however, that those together with the rest of the paragraph and two further references are all taken from the source, which has been translated.

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