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Typus
BauernOpfer
Bearbeiter
Graf Isolan
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Untersuchte Arbeit:
Seite: 9, Zeilen: 1-14
Quelle: Firth and Baxter 2002
Seite(n): 826, Zeilen: left col. 8-12, (12-16), 16-20, 30-38
[Using] exogenous IGFBPs, Boes et al. (Boes et al., 1992) demonstrated in an isolated perfused heart model that IGFBP-4, after crossing the capillary endothelium, preferentially localizes to connective tissue rather than cardiac muscle, the exact distribution depending on the glycosylation state. In contrast, IGFBP-1, -2, and -3 are preferentially localized to cardiac muscle. IGFBP-3 injected intravenously appears initially in the liver (40% of injected dose) and kidney (4%), within 5 min after administration (Arany et al., 1996).

All six IGFBPs are also found in the circulation in the free form or in bound binary and/or ternary complexes with IGFs. In the circulation the majority of IGF is associated with IGFBP-3 and -5 in a ternary complex that also contain ALS, a leucine-rich-glycoprotein (Baxter et al., 1989; Baxter et al., 2002; Twigg et al., 1998; Twigg et al., 2000). The ternary complexes appear to be essentially confined to the vascular compartment whereas free or binary-complexed IGFBPs are believed to exit the circulation rapidly (Guler et al., 1989; Lewitt et al., 1994; Young et al., 1992).


Arany E, Zabel P, Hill DJ. 1996. Rapid clearance of human insulin-like growth factor binding protein-3 from the rat circulation and cellular localization in liver, kidney and stomach. Growth Regul 6(1):32-41.

Baxter RC, Martin JL, Beniac VA. 1989. High molecular weight insulin-like growth factor binding protein complex. Purification and properties of the acid-labile subunit from human serum. J Biol Chem 264(20):11843-11848.

Baxter RC, Meka S, Firth SM. 2002. Molecular distribution of IGF binding protein-5 in human serum. J Clin Endocrinol Metab 87(1):271-276.

Boes M, Booth BA, Sandra A, Dake BL, Bergold A, Bar RS. 1992. Insulin-like growth factor binding protein (IGFBP)4 accounts for the connective tissue distribution of endothelial cell IGFBPs perfused through the isolated heart. Endocrinology 131(1):327-330.

Guler HP, Zapf J, Schmid C, Froesch ER. 1989. Insulin-like growth factors I and II in healthy man. Estimations of half-lives and production rates. Acta Endocrinol (Copenh) 121(6):753-758.

Lewitt MS, Saunders H, Phuyal JL, Baxter RC. 1994. Complex formation by human insulin-like growth factor-binding protein-3 and human acid-labile subunit in growth hormone-deficient rats. Endocrinology 134(6):2404-2409.

Twigg SM, Kiefer MC, Zapf J, Baxter RC. 1998. Insulin-like growth factor-binding protein 5 complexes with the acid-labile subunit. Role of the carboxyl-terminal domain. J Biol Chem 273(44):28791-28798.

Twigg SM, Kiefer MC, Zapf J, Baxter RC. 2000. A central domain binding site in insulin-like growth factor binding protein-5 for the acid-labile subunit. Endocrinology 141(1):454-457.

Young SC, Miles MV, Clemmons DR. 1992. Determination of the pharmacokinetic profiles of insulin-like growth factor binding proteins-1 and -2 in rats. Endocrinology 131(4):1867-1873.

In brief, the major IGF transport function can be attributed to IGFBP-3, the most abundant circulating IGFBP. It carries 75% or more of serum IGF-I and IGF-II in heterotrimeric complexes that also contain ALS, a leucine-rich glycoprotein of approximately 85 kDa (44). IGFBP-5, present at about 10% of the molar concentration of IGFBP-3, can form similar ternary complexes (45). Approximately 90% of IGFBP-3 and 55% of IGFBP-5 circulate in these complexes in healthy adults (46). All six IGFBPs are also found in the circulation in the free form or in binary complexes with IGFs. Free or binary-complexed IGFBPs are believed to exit the circulation rapidly, whereas ternary complexes appear to be essentially confined to the vascular compartment (47–49).

[...]

Using exogenous IGFBPs, Boes et al. (51) demonstrated in an isolated perfused heart model that IGFBP-4, after crossing the capillary endothelium, preferentially localizes to connective tissue rather than cardiac muscle, the exact distribution depending on the glycosylation state. In contrast, IGFBP-1, -2, and -3 are preferentially localized to cardiac muscle. IGFBP-3 injected iv appears initially in the liver (40% of injected dose) and kidney (4%), within 5 min of administration (52). Uptake by muscle was not examined in this study.


25. Twigg SM, Kiefer MC, Zapf J, Baxter RC 1998 Insulin-like growth factor-binding protein 5 complexes with the acid-labile subunit: role of the carboxyl-terminal domain. J Biol Chem 273:28791–28798

36. Twigg SM, Kiefer MC, Zapf J, Baxter RC 2000 A central domain binding site in insulin-like growth factor-binding protein 5 for the acid-labile subunit. Endocrinology 141:454–457

44. Baxter RC, Martin JL, Beniac VA 1989 High molecular weight insulin-like growth factor binding protein complex. Purification and properties of the acid-labile subunit from human serum. J Biol Chem 264:11843–11848

45. Twigg SM, Baxter RC 1998 Insulin-like growth factor (IGF)-binding protein 5 forms an alternative ternary complex with IGFs and the acid-labile subunit. J Biol Chem 273:6074–6079

46. Baxter RC, Meka S, Firth SM 2002 Molecular distribution of IGF-binding protein-5 in human serum. J Clin Endocrinol Metab 87: 271–276

47. Guler H-P, Zapf J, Schmid C, Froesch ER 1989 Insulin-like growth factors I and II in healthy man. Estimations of half-lives and production rates. Acta Endocrinol (Copenh) 121:753–758

48. Young SCJ, Miles MV, Clemmons DR 1992 Determination of the pharmacokinetic profiles of insulin-like growth factor binding proteins-1 and -2 in rats. Endocrinology 131:1867–1873

49. Lewitt MS, Saunders H, Phuyal JL, Baxter RC 1994 Complex formation by human insulin-like growth factor-binding protein-3 and human acid-labile subunit in growth hormone-deficient rats. Endocrinology 134:2404–2409

51. Boes M, Booth BA, Sandra A, Dake BL, Bergold A, Bar RS 1992 Insulin-like growth factor binding protein (IGFBP)4 accounts for the connective tissue distribution of endothelial cell IGFBPs perfused through the isolated heart. Endocrinology 131:327–330

52. Arany E, Zabel P, Hill DJ 1996 Rapid clearance of human insulin-like growth factor binding protein-3 from the rat circulation and cellular localization in liver, kidney and stomach. Growth Regul 6:32–41

Anmerkungen

In-between some of the facts have been condensed by Rrp, otherwise the texts are nearly identical. Nothing has been marked as a citation, with the source not being mentioned.

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