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| Untersuchte Arbeit: Seite: 9, Zeilen: 1 ff. |
Quelle: Smith 2003 Seite(n): Internet, Zeilen: Internet |
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| [Some of the most important] lymphoid cells include natural killer (NK) cells,T cells, and B cells, while important myeloid cells include granulocytes, monocytes, macrophages, microglial cells, and dendritic cells [7]. Each of these cell types can be generated from a single HSC, and each HSC has an enormous capacity to generate large numbers of these cells over many years and perhaps even decades. In the mouse, a single HSC can reconstitute the entire hematopoietic system for the natural lifespan of the animal [8]. HSC are detected in the bone marrow at a frequency between 1: 107 - 108 [9]. While HSC are primarily found in the bone marrow, they are present in a variety of other tissues including peripheral blood and umbilical cord blood, and are found at low numbers in the liver, spleen, and perhaps many organs [10]. These HSC may have somewhat different properties, but they all have the ability to generate all the different blood lineages in large numbers for a prolonged period of time.
Downstream of the common lymphoid progenitors (CLPs) and common myeloid progenitors (CMPs) are more mature progenitors that are further restricted in the number and type of lineages that they can generate [11, 12]. When a bone marrow or blood stem cell transplant is performed, it appears that progenitors contribute to engraftment for only a short period of time, while long-term blood production is derived primarily from HSC [13]. |
Some of the most important lymphoid cells include natural killer (NK) cells,T cells, and B cells, while important myeloid cells include granulocytes, monocytes, macrophages, microglial cells, and dendritic cells.[5] Each of these cell types can be generated from a single HSC, and each HSC has an enormous capacity to generate large numbers of these cells over many years and perhaps even decades. In the mouse, a single HSC can reconstitute the entire hematopoietic system for the natural lifespan of the animal.[6] Murine HSCs are rare and are present at a frequency of 1/10,000 to 1/1,000,000 cells in the bone marrow depending on the species, age, and technical aspects of the model. While HSCs are primarily found in the bone marrow, they are present in a variety of other tissues including peripheral blood and umbilical cord blood, and are found at low numbers in the liver, spleen, and perhaps many organs.[7] These HSCs may have somewhat different properties, but they all have the ability to generate all the different blood lineages in large numbers for a prolonged period of time.
[...] Downstream of the CLPs and CMPs are more mature progenitors that are further restricted in the number and type of lineages that they can generate.[10] [...] When a bone marrow or blood stem cell transplant is performed, it appears that progenitors contribute to engraftment for only a short period of time, while long-term blood production is derived primarily from HSCs.[12] |
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