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Untersuchte Arbeit:
Seite: 17, Zeilen: 1-9
Quelle: Martinez-Agosto et al. 2007
Seite(n): 3054, 3055, Zeilen: -
[C-myc has been shown to be an important cell intrinsic regulator required for HSC homeostasis regulating the release of HSC] from the quiescence-promoting niche. Upon conditional ablation of c-myc in bone marrow HSC, these stem cells are unable to differentiate as they increase adhesion molecules on their surface and remain anchored to the niche that retains them in a quiescent, undifferentiated state [66]. Although the osteoblast endosteal niche of the mouse bone marrow is so far the best characterized hematopoietic niche, the majority of the HSC that engraft in transplantation assays actually localize in perivascular spaces, in contact with sinusoidal venous endothelium [67], leading to the speculation that these surfaces may provide additional niche-like interactions for the maintenance of adult HSC. C-myc has been shown to be an important cell intrinsic regulator required for HSC homeostasis regulating the release of HSCs from the quiescence-promoting niche. Upon conditional ablation of c-myc in bone marrow HSCs, these stem cells are unable to differentiate as they increase adhesion molecules on their surface and remain anchored to the niche that retains them in a quiescent, undifferentiated state (Wilson et al. 2004). Although the osteoblast endosteal niche of the mouse bone marrow is so far the best characterized hematopoietic niche, the

[S. 3055]

majority of the HSCs that engraft in transplantation assays actually localize in perivascular spaces, in contact with sinusoidal venous endothelium (Kiel et al. 2005), leading to the speculation that these surfaces may provide additional niche-like interactions for the maintenance of adult HSCs.

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