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Untersuchte Arbeit:
Seite: 17, Zeilen: 10 ff.
Quelle: Mukhopadhyay et al. 2004
Seite(n): 221, Zeilen: 5 ff.
1.5 The clinical demand on HSC:

Bone Marrow Transplantation (BMT) is a life saving procedure for a number of malignant and non-malignant life threatening diseases [68]. Ever since the first successful BMT in the late 1960s, an increasing number of BMT and related procedures are being performed world wide. Allogeneic stem cell (unrelated human leucocyte antigen, HLA identical donor) transplantation is now a curative treatment modality for a number of disorders, including malignant diseases, dyserythropoiesis, bone marrow aplasia, immunodeficiency states, and a number of inherited disorders [69].

The indications for hematopoietic stem cell transplantation [69] can be conveniently divided into two groups: (a) Malignant disorders: like leukemias, lymphomas, multiple myeloma and solid tumors like breast cancer, testicular cancer. In all these indications, the cure or palliation is by the high doses of chemotherapy or radiation therapy, while the transplant serves to rescue the patient from the myelotoxic effects of the anti-cancer therapy. In allogeneic type of transplants, there is an additional immunological advantage of graft vs cancer effect, which contributes to the disease relief; (b) Non-malignant diseases: like aplastic anemia, thalassemia, Gaucher's disease, etc. In these conditions the abnormal marrow is deliberately destroyed and replaced by the healthy donor marrow. In this setting autologous (patient's own stem cells) transplantation cannot be effective for obvious reasons.


68. Armitage JO., N Engl J Med 1994, 330:827

69 Gratwohl A, Passweg J, Baldomero H,Urbano-Ispizua A., Bone Marrow Transplant, 2001, 27,899

3 Clinical Applications of Hematopoietic Stem Cells

Bone Marrow Transplantation (BMT) is a life saving procedure for a number of malignant and non-malignant life threatening diseases [46]. Ever since the first successful BMT in the late 1960s, an increasing number of BMT and related procedures are being performed worldwide. Allogeneic stem cell (unrelated human leucocyte antigen, HLA identical donor) transplantation is now a curative treatment modality for a number of disorders, including malignant diseases, dyserythropoiesis, bone marrow aplasia, immunodeficiency states, and a number of inherited disorders [47].

The indications for hematopoietic stem cell transplantation [47] can be conveniently divided into two groups: (a) Malignant disorders: like leukemias, lymphomas, multiple myeloma and solid tumors like breast cancer, testicular cancer. In all these indications, the cure or palliation is by the high doses of chemotherapy or radiation therapy, while the transplant serves to rescue the patient from the myelotoxic effects of the anti-cancer therapy. In allogeneic type of transplants, there is an additional immunological advantage of graft vs cancer effect, which contributes to the disease relief; (b) Non-malignant diseases: like aplastic anemia, thalassemia, Gaucher’s disease, etc. In these conditions the abnormal marrow is deliberately destroyed and replaced by the healthy donor marrow. In this setting autologous (patient’s own stem cells) transplantation cannot be effective for obvious reasons.


46. Armitage JO (1994) N Engl J Med 330:827

47. Gratwohl A, Passweg J, Baldomero H, Urbano-Ispizua A (2001) Bone Marrow Transplant 27,899

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