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Seite: 18, Zeilen: 1-15
Quelle: Mukhopadhyay et al. 2004
Seite(n): 221, Zeilen: -
Bone marrow and stem cell transplantation is curative in many potentially fatal conditions. The graft vs tumor effect seen after allogeneic transplants for human malignancies represents the clearest example of the power of the human immune system to eradicate cancer [70, 71]. It is likely that in future the high dose preparative regimens used in allogeneic bone marrow and stem cell transplants will be replaced with less toxic therapy leading to a safer transplant procedure. Autologous transplants are mainly done for lymphomas, solid malignancies like neuroblastoma and germinal cancers, hematological malignancies like multiple myeloma [72], and in patients with acute leukemia who do not have an HLA identical donor. The advantage of autologous transplant over allogeneic transplant is that there is no graft vs host disease (GVHD), and once engraftment occurs then graft rejection is unlikely. Thus there is a significant decrease in the complication rate as compared to the allogenic transplantation; however risk of tumor relapse is higher as compared to the allogeneic transplantation.

70 McSweeney PA,Niederwieser D, Shizuru JA et al., Blood, 2001, 97:3390

71 Appelbaum FR., Nature 2001, 411:385

72 Rajkumar SV, Fonesca R,Dispenzieri A et al., Bone Marrow Transplant 2000, 26:979

Bone marrow and stem cell transplantation is curative in many potentially fatal conditions. [...] The graft vs tumor effect seen after allogeneic transplants for human malignancies represents the clearest example of the power of the human immune system to eradicate cancer [50, 51]. It is likely that in future the high dose preparative regimens used in allogeneic bone marrow and stem cell transplants will be replaced with less toxic therapy leading to a safer transplant procedure. Autologous transplants are mainly done for lymphomas, solid malignancies like neuroblastoma and germinal cancers, hematological malignancies like multiple myeloma [52], and in patients with acute leukemia who do not have an HLA identical donor. The advantage of autologous transplant over allogeneic transplant is that there is no graft vs host disease (GVHD), and once engraftment occurs then graft rejection is unlikely. Thus there is a significant decrease in the complication rate as compared to the allogenic transplantation; however risk of tumor relapse is higher as compared to the allogeneic transplantation.

50. McSweeney PA, Niederwieser D, Shizuru JA et al. (2001) Blood 97:3390

51. Appelbaum FR (2001) Nature 411:385

52. Rajkumar SV, Fonesca R, Dispenzieri A et al. (2000) Bone Marrow Transplant 26:979

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