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Untersuchte Arbeit:
Seite: 18, Zeilen: 16 ff.
Quelle: Domen et al. 2006
Seite(n): 22, Zeilen: -
1.6 Sources of HSC:

1.6.1 Bone Marrow and Mobilized Peripheral Blood

The best-known location for HSC is bone marrow, and bone marrow transplantation has become synonymous with hematopoietic cell transplantation.

In adults, under steady state conditions, the majority of HSC reside in bone marrow. However, cytokine mobilization can result in the release of large numbers of HSC into the blood. As a clinical source of HSC, mobilized peripheral blood (MPB) is now replacing bone marrow, as harvesting peripheral blood is easier for the donors than harvesting bone marrow.

1.6.2 Umbilical Cord Blood

In the late 1980s, umbilical cord blood (UCB) was recognized as an important clinical source of HSC [73, 74]. Blood from the placenta and umbilical cord is a rich source of hematopoietic stem cells, and these cells are typically discarded [with the afterbirth.]

SOURCES OF HSCS

Bone Marrow and Mobilized Peripheral Blood

The best-known location for HSCs is bone marrow, and bone marrow transplantation has become synonymous with hematopoietic cell transplantation, even though bone marrow itself is increasingly infrequently used as a source due to an invasive harvesting procedure that requires general anesthesia. In adults, under steadystate conditions, the majority of HSCs reside in bone marrow. However, cytokine mobilization can result in the release of large numbers of HSCs into the blood. As a clinical source of HSCs, mobilized peripheral blood (MPB) is now replacing bone marrow, as harvesting peripheral blood is easier for the donors than harvesting bone marrow. [...]

Umbilical Cord Blood

In the late 1980s, umbilical cord blood (UCB) was recognized as an important clinical source of HSCs.100,101 Blood from the placenta and umbilical cord is a rich source of hematopoietic stem cells, and these cells are typically discarded with the afterbirth.

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