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Graf Isolan
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Untersuchte Arbeit:
Seite: 20, Zeilen: 4-9
Quelle: Eschenhagen und Zimmermann 2005
Seite(n): 1220, Zeilen: li. Sp. 11-17
The second approach can be synonymous with, “cell therapy” which intends to promote the formation of new tissue or to improve the function of an existing tissue by injecting or infusing suspensions of isolated cells. This concept has gained much attraction over the past years; studies have been performed in animals 53, 164, 167, 168, 307 and are currently tested in controlled clinical trials 70, 173, 207, 208, 220, 221, 318, 370.

53. Chiu RC, Zibaitis A, Kao RL (1995) Cellular cardiomyoplasty: myocardial regeneration with satellite cell implantation. Ann Thorac Surg 60 (1):12-8

70. Dimmeler S, Zeiher AM, Schneider MD (2005) Unchain my heart: the scientific foundations of cardiac repair. J Clin Invest 115 (3):572-83

164. Klug MG, Soonpaa MH, Koh GY, Field LJ (1996) Genetically selected cardiomyocytes from differentiating embronic stem cells form stable intracardiac grafts. J Clin Invest 98 (1):216-24

167. Koh GY, Klug MG, Soonpaa MH, Field LJ (1993) Differentiation and long-term survival of C2C12 myoblast grafts in heart. J Clin Invest 92 (3):1548-54

168. Koh GY, Soonpaa MH, Klug MG, Field LJ (1993) Long-term survival of AT-1 cardiomyocyte grafts in syngeneic myocardium. Am J Physiol 264 (5):1727-33

173. Laflamme MA, Murry CE (2005) Regenerating the heart. Nat Biotechnol 23 (7):845-56

207. Menasche P (2005) Skeletal myoblast for cell therapy. Coron Artery Dis 16 (2):105-10

208. Menasche P, Hagege AA, Scorsin M, Pouzet B, Desnos M, Duboc D, Schwartz K, Vilquin JT, Marolleau JP (2001) Myoblast transplantation for heart failure. Lancet 357 (9252):279-80

220. Murry CE, Whitney ML, Laflamme MA, Reinecke H, Field LJ (2002) Cellular therapies for myocardial infarct repair. Cold Spring Harb Symp Quant Biol 67 519-26

221. Nadal-Ginard B, Kajstura J, Anversa P, Leri A (2003) A matter of life and death: cardiac myocyte apoptosis and regeneration. J Clin Invest 111 (10):1457-9

307. Soonpaa MH, Koh GY, Klug MG, Field LJ (1994) Formation of nascent intercalated disks between grafted fetal cardiomyocytes and host myocardium. Science 264 (5155):98-101

318. Strauer BE, Brehm M, Zeus T, Gattermann N, Hernandez A, Sorg RV, Kogler G, Wernet P (2001) [Intracoronary, human autologous stem cell transplantation for myocardial regeneration following myocardial infarction]. Dtsch Med Wochenschr 126 (34-35):932-8

370. von Harsdorf R, Poole-Wilson PA, Dietz R (2004) Regenerative capacity of the myocardium: implications for treatment of heart failure. Lancet 363 (9417):1306-13

The “repair” part of tissue engineering overlaps, but is not synonymous with, “cell therapy” which intends to promote the formation of new tissue or to improve the function of an existing tissue by injecting or infusing suspensions of isolated cells. This concept has gained much attraction over the past years and is currently tested in controlled clinical trials (for review see references 1–6).

1. Murry CE, Whitney ML, Laflamme MA, Reinecke H, Field LJ. Cellular therapies for myocardial infarct repair. Cold Spring Harb Symp Quant Biol. 2002;67:519–526.

2. Nadal-Ginard B, Kajstura J, Anversa P, Leri A. A matter of life and death: cardiac myocyte apoptosis and regeneration. J Clin Invest. 2003; 111:1457–1459.

3. von Harsdorf R, Poole-Wilson PA, Dietz R. Regenerative capacity of the myocardium: implications for treatment of heart failure. Lancet. 2004; 363:1306–1313.

4. Dimmeler S, Zeiher AM, Schneider MD. Unchain my heart: the scientific foundations of cardiac repair. J Clin Invest. 2005;115:572–583.

5. Menasche P. Skeletal myoblast for cell therapy. Coron Artery Dis. 2005;16:105–110.

6. Laflamme MA, Murry CE. Regenerating the heart. Nat Biotechnol. 2005;23:845– 856.

Anmerkungen

Wörtlich übereinstimmend; ohne Hinweis auf die eigentliche Quelle (vgl. auch Sih/Fragment_019_17). Die in der Quelle angegebenen Literaturangaben sind alle bei Sih wiederzufinden.

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