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Untersuchte Arbeit:
Seite: 21, Zeilen: 5-13
Quelle: Wikipedia NMDA receptor 2013
Seite(n): 1 (online source), Zeilen: -
1.3.3. NMDA RECEPTOR

The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR) is the predominant molecular device for controlling synaptic plasticity and memory function. Activation of NMDRs results in the opening of an ion channel that is nonselective to cations with an equilibrium potential near 0 mV. A property of the NMDA receptor is its voltage-dependent activation, a result of ion channel blocked by extracellular Mg2+ & Zn2+ ions. This allows the flow of Na+ and Ca2+ ions into the cell and K+ out of the cell to be voltage-dependent (Dingledine et al., 1999; Liu et al., 2000; Cull et al., 2001; Paoletti et al., 2007).

NMDA receptor

[...]

The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), a glutamate receptor, is the predominant molecular device for controlling synaptic plasticity and memory function.[2]

[...] Activation of NMDA receptors results in the opening of an ion channel that is nonselective to cations with an equilibrium potential near 0 mV. A property of the NMDA receptor is its voltage-dependent activation, a result of ion channel block by extracellular Mg2+ & Zn2+ ions. This allows the flow of Na+ and small amounts of Ca2+ ions into the cell and K+ out of the cell to be voltage-dependent.[3][4][5][6]


2. Clinical Implications of Basic Research: Memory and the NMDA receptors, Fei Li and Joe Z. Tsien, N Engl J Med, 361:302, July 16, 2009

3. Dingledine R, Borges K, Bowie D, Traynelis SF (March 1999). "The glutamate receptor ion channels". Pharmacol. Rev. 51 (1): 7–61. PMID 10049997.

4. Liu Y, Zhang J (October 2000). "Recent development in NMDA receptors". Chin. Med. J. 113 (10): 948–56. PMID 11775847.

5. Cull-Candy S, Brickley S, Farrant M (June 2001). "NMDA receptor subunits: diversity, development and disease". Curr. Opin. Neurobiol. 11 (3): 327–35. doi:10.1016/S0959-4388(00)00215-4. PMID 11399431.

6. Paoletti P, Neyton J (February 2007). "NMDA receptor subunits: function and pharmacology". Curr Opin Pharmacol 7 (1): 39–47. doi:10.1016/j.coph.2006.08.011. PMID 17088105.

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