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A new insight on direct actions of Granulocyte-Colony Stimulating Factor in the myocardium

von Dr. Ana Catarina Ribeiro Carrão

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[1.] Arc/Fragment 012 03 - Diskussion
Zuletzt bearbeitet: 2014-02-25 21:58:12 Hindemith
Arc, Demetri and Griffin 1991, Fragment, Gesichtet, SMWFragment, Schutzlevel sysop, Verschleierung

Typus
Verschleierung
Bearbeiter
Graf Isolan
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 12, Zeilen: 3-11
Quelle: Demetri and Griffin 1991
Seite(n): 2791, Zeilen: left col. 1-14
Granulocyte-colony stimulating factor (G-CSF) is a polypeptide growth factor that regulates the production of neutrophilic granulocytes. This physiological process serves as the foundation for critical host defence systems and occurs on a large scale in vivo. An adult of average size will produce approximately 120 billion granulocytes per day simply to replace normal losses1. This enormous production capacity may be increased by at least 10-fold under stress conditions such as infection. G-CSF plays a pivotal role in the basal regulation of neutrophil production as well as functioning as a primary regulatory factor controlling the neutrophil response to inflammatory stimuli. Also, G-CSF exhibits other biological activities and G-CSF-induced hematopoietic stem cell mobilization is widely used clinically for peripheral blood stem cell transplantation.

1. Basu S, Dunn A, Ward A. G-CSF: function and modes of action (Review). Int J Mol Med. 2002;10:3-10.

GRANULOCYTE colony-stimulating factor (G-CSF) is a polypeptide growth factor that regulates the production of neutrophilic granulocytes. This physiologic process serves as the foundation for critical host defense systems and occurs on a large scale in vivo. An adult of average size will produce approximately 120 billion granulocytes per day simply to replace normal losses. This enormous production capacity may be increased by at least 10-fold under stress conditions such as infection. G-CSF is likely to play a role in the basal regulation of neutrophil production as well as to function as a primary regulatory factor controlling the neutrophil response to inflammatory stimuli. Further, G-CSF exhibits other biologic activities besides proliferative effects: [...]
Anmerkungen

This passage is not recognizable as a citation.

Sichter
(Graf Isolan) Schumann

[2.] Arc/Fragment 012 19 - Diskussion
Zuletzt bearbeitet: 2014-02-26 21:57:37 Schumann
Arc, BauernOpfer, Demetri and Griffin 1991, Fragment, Gesichtet, SMWFragment, Schutzlevel sysop

Typus
BauernOpfer
Bearbeiter
Graf Isolan
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 12, Zeilen: 19-29
Quelle: Demetri and Griffin 1991
Seite(n): 2791, Zeilen: left col. 16-32
G-CSF possesses unique and interesting characteristics among the family of hematopoietic growth factors. This chapter will summarize the current state of knowledge of the structure and function of G-CSF and its receptor.

I.1 Identification of G-CSF and its gene

The identification of CSFs was made possible by cell culture assays for hematopoietic progenitor cells developed in the mid 1960s by Metcalf and his colleagues2. These in vitro systems showed that the survival, proliferation, and differentiation of immature hematopoietic cells were dependent on the continued presence of humoral factors, which was collectively termed “colony-stimulating activity” (CSA)3. Before the purification of individual factors, early sources of CSA [included media that was conditioned by stimulated cultures of normal blood or certain tumour cells.]


2. Bradley TR, Robinson W, Metcalf D. Colony production in vitro by normal polycythaemic and anaemic bone marrow. Nature. 1967;214:511.

3. Demetri GD, Griffin JD. Granulocyte colony-stimulating factor and its receptor. Blood. 1991;78:2791-2808.

G-CSF possesses unique and interesting characteristics among the family of hematopoietic growth factors. This review will summarize the current state of knowledge of the structure and function of G-CSF and its receptor.

IDENTIFICATION OF G-CSF

The identification of CSFs was made possible by the cell culture assays for hematopoietic progenitor cells, which were developed in the mid 1960s independently by Metcalf, Sachs, and their colleagues. These in vitro systems showed that the survival, proliferation, and differentiation of immature hematopoietic cells were dependent on the continued presence of humoral factors, which were collectively termed “colony-stimulating activity” (CSA). Before the purification of individual factors, early sources of CSA included media conditioned by culture with stimulated normal blood or splenic leukocytes, placenta, or certain tumor cells1-5.


1. Metcalf D: The granulocyte-macrophage colony-stimulating factors. Science 229:16, 1985

2. Metcalf D: The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells. Nature 339:27, 1989

3. Sachs L The molecular control of blood cell development. Science 238:1374, 1987

4. Quesenberry P, Levitt L Hematopoietic stem cells. N Engl J Med 301:755,1979

5. Golde D, Cline M: Regulation of granulopoiesis. N Engl J Med 291:1388,1974

Anmerkungen

At the end of the page the source is given. Nevertheless nothing has been marked as a citation and it is not clear to the reader that even the end of the previous section is taken verbatim from the source.

Sichter
(Graf Isolan), Hindemith


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