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A new insight on direct actions of Granulocyte-Colony Stimulating Factor in the myocardium

von Dr. Ana Catarina Ribeiro Carrão

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Statistik und Sichtungsnachweis dieser Seite findet sich am Artikelende
[1.] Arc/Fragment 018 25 - Diskussion
Zuletzt bearbeitet: 2014-02-26 22:12:28 Schumann
Arc, BauernOpfer, Fragment, Gesichtet, SMWFragment, Sampson et al 2007, Schutzlevel sysop

Typus
BauernOpfer
Bearbeiter
Graf Isolan
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 18, Zeilen: 25-31
Quelle: Sampson et al 2007
Seite(n): 1 (online source), Zeilen: -
G-CSF is an essential growth factor for the optimal production of neutrophils and their precursors. When either G-CSF or its cognate receptor are genetically ablated, the resulting mice are severely neutropenic and susceptible to opportunistic infections20, 40, 41. The loss of G-CSF signalling accounts for the defects on proliferation, differentiation and survival at the progenitor, precursor or terminally differentiated neutrophil stages. The structural functional analysis of the G-CSFR attributes proliferative signalling to the proximal domain (~60 amino acids proximal to the plasma [membrane) and differentiation signalling to the distal domain (~100 amino acids at the C-terminus)29.]

20. Lieschke GJ, Grail D, Hodgson G, Metcalf D, Stanley E, Cheers C, Fowler KJ, Basu S, Zhan YF, Dunn AR. Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization. Blood. 1994;84:1737-1746.

29. Sampson M, Zhu QS, Corey SJ. Src kinases in G-CSF receptor signaling. Front Biosci. 2007;12:1463-1474.

40. Hermans MH, Ward AC, Antonissen C, Karis A, Lowenberg B, Touw IP. Perturbed granulopoiesis in mice with a targeted mutation in the granulocyte colony-stimulating factor receptor gene associated with severe chronic neutropenia. Blood. 1998;92:32-39.

41. Liu F, Poursine-Laurent J, Link DC. The granulocyte colony-stimulating factor receptor is required for the mobilization of murine hematopoietic progenitors into peripheral blood by cyclophosphamide or interleukin-8 but not flt-3 ligand. Blood. 1997;90:2522-2528.

2. INTRODUCTION

[...]

G-CSF is an essential growth factor for the optimal production of neutrophils and their precursors. When either G-CSF or its cognate receptor is genetically ablated, the resulting mice are severely neutropenic and susceptible to opportunistic infections (3-6). Loss of G-CSF signaling for proliferation, differentiation, and survival at the progenitor, precursor, or terminally differentiated neutrophil stages accounts for these defects. [...]


6. TYROSINE PHOSPHORYLATION OF THE G-CSF RECEPTOR

Structural functional analysis of the G-CSF Receptor attributes proliferative signaling to the proximal domain (~60 amino acids proximal to the plasma membrane) and differentiation to the distal domain (~100 amino acids at the C-terminus) (Figure 1).


3. Hermans, M. H., A. C. Ward, C. Antonissen, A. Karis, B. Lowenberg & I. P. Touw: Perturbed granulopoiesis in mice with a targeted mutation in the granulocyte colony-stimulating factor receptor gene associated with severe chronic neutropenia. Blood, 92, 32-9 (1998)


4. Lieschke, G. J., D. Grail, G. Hodgson, D. Metcalf, E. Stanley, C. Cheers, K. J. Fowler, S. Basu, Y. F. Zhan & A. R. Dunn: Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization. Blood, 84, 1737-46 (1994)


5. Liu, F., J. Poursine-Laurent & D. C. Link: The granulocyte colony-stimulating factor receptor is required for the mobilization of murine hematopoietic progenitors into peripheral blood by cyclophosphamide or interleukin-8 but not flt-3 ligand. Blood, 90, 2522-8 (1997)


6. Liu, F., H. Y. Wu, R. Wesselschmidt, T. Kornaga & D. C. Link: Impaired production and increased apoptosis of neutrophils in granulocyte colony-stimulating factor receptor-deficient mice. Immunity, 5, 491-501 (1996) 10.1016/S1074-7613 (00)80504-X

Anmerkungen

Though the source is named in the end nothing has been marked as a citation.

Also the references to the literature have been taken from the source.

Sichter
(Graf Isolan), Hindemith


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Letzte Bearbeitung dieser Seite: durch Benutzer:Hindemith, Zeitstempel: 20140226103905

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