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A new insight on direct actions of Granulocyte-Colony Stimulating Factor in the myocardium

von Dr. Ana Catarina Ribeiro Carrão

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Statistik und Sichtungsnachweis dieser Seite findet sich am Artikelende
[1.] Arc/Fragment 049 02 - Diskussion
Zuletzt bearbeitet: 2014-02-26 23:07:25 Guckar
Arc, Fragment, Gesichtet, SMWFragment, Schutzlevel sysop, Toyota et al 2005, Verschleierung

Typus
Verschleierung
Bearbeiter
Hindemith
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 49, Zeilen: 2-11
Quelle: Toyota et al 2005
Seite(n): 2109, 2110, Zeilen: 2109: r.col: last two lines; 2110: l.col: 1ff
Evaluation of collateral growth was performed after completion of the protocol by a simple functional test: total coronary occlusion. The rationale for this procedure was that if collaterals were developed, then occlusion would not induce functional disturbances. Alternatively, if collaterals were not mature, then occlusion would cause hemodynamic disturbances. After the second measurement of coronary blood flow, the coronary occlusion was maintained, systemic hemodynamics were measured and also the number of arrhythmias. In animals without collaterals, coronary occlusion caused deterioration of systemic hemodynamics and arrhythmias, including premature ventricular contractions, ventricular tachycardia, and ventricular fibrillation; in animals with well developed collaterals, no such adverse effects were noted. We evaluated collateral growth after completion of the protocol by a simple functional test: total coronary occlusion. The rationale for this

[page 2110]

procedure was that if collaterals were developed, then occlusion would not induce functional disturbances. Alternatively, if collaterals were not mature, then occlusion would cause hemodynamic disturbances. After the second measurement of coronary blood flow, we maintained the coronary occlusion (n=9 in control group, n=6 in anti-VEGF group) and measured systemic hemodynamics and the number of arrhythmias. In animals without collaterals, coronary occlusion caused deterioration of systemic hemodynamics and arrhythmias, including premature ventricular contractions, ventricular tachycardia, and ventricular fibrillation; in animals with well-developed collaterals, no such adverse effects were noted.

Anmerkungen

The source is not mentioned here.

Sichter
(Hindemith) Agrippina1

[2.] Arc/Fragment 049 14 - Diskussion
Zuletzt bearbeitet: 2014-02-26 23:07:35 Guckar
Arc, Fragment, Gesichtet, SMWFragment, Schutzlevel sysop, Toyota et al 2005, Verschleierung

Typus
Verschleierung
Bearbeiter
Hindemith
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 49, Zeilen: 14-19
Quelle: Toyota et al 2005
Seite(n): 2109, Zeilen: r.col: 36-42
After the completion of treatments, the heart was removed, and the left ventricle (LV) was sliced along the short axis and observed with a dissecting microscope under fluorescent light. The collateral-dependent area (LAD region, ischemic zone) was distinguished as the area without fluorescent microspheres. The control area (non-LAD LV region, normal zone) was determined by the area of distribution of the fluorescent microspheres (Fig. 13). The heart was excised and fixed in 4% paraformaldehyde solution overnight. The fixed LV was sliced along the short axis and observed with a dissecting microscope and fluorescent light source (LT-9800, Lightools Research). The collateral-dependent area (LAD region) was distinguished as the area without fluorescent microspheres. The control area (non-LAD LV region) was determined by the area distribution of the fluorescent microspheres.
Anmerkungen

The source is not given. To be continued on the next page: Arc/Fragment_050_01

Note that a similar text can also be found further up in the thesis, c.f. Arc/Fragment_042_16, Arc/Fragment_043_01

Sichter
(Hindemith) Schumann


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