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Typus
Verschleierung
Bearbeiter
Graf Isolan
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 12, Zeilen: 3-11
Quelle: Demetri and Griffin 1991
Seite(n): 2791, Zeilen: left col. 1-14
Granulocyte-colony stimulating factor (G-CSF) is a polypeptide growth factor that regulates the production of neutrophilic granulocytes. This physiological process serves as the foundation for critical host defence systems and occurs on a large scale in vivo. An adult of average size will produce approximately 120 billion granulocytes per day simply to replace normal losses1. This enormous production capacity may be increased by at least 10-fold under stress conditions such as infection. G-CSF plays a pivotal role in the basal regulation of neutrophil production as well as functioning as a primary regulatory factor controlling the neutrophil response to inflammatory stimuli. Also, G-CSF exhibits other biological activities and G-CSF-induced hematopoietic stem cell mobilization is widely used clinically for peripheral blood stem cell transplantation.

1. Basu S, Dunn A, Ward A. G-CSF: function and modes of action (Review). Int J Mol Med. 2002;10:3-10.

GRANULOCYTE colony-stimulating factor (G-CSF) is a polypeptide growth factor that regulates the production of neutrophilic granulocytes. This physiologic process serves as the foundation for critical host defense systems and occurs on a large scale in vivo. An adult of average size will produce approximately 120 billion granulocytes per day simply to replace normal losses. This enormous production capacity may be increased by at least 10-fold under stress conditions such as infection. G-CSF is likely to play a role in the basal regulation of neutrophil production as well as to function as a primary regulatory factor controlling the neutrophil response to inflammatory stimuli. Further, G-CSF exhibits other biologic activities besides proliferative effects: [...]
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(Graf Isolan) Schumann

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