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Typus
BauernOpfer
Bearbeiter
Graf Isolan
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Untersuchte Arbeit:
Seite: 12, Zeilen: 19-29
Quelle: Demetri and Griffin 1991
Seite(n): 2791, Zeilen: left col. 16-32
G-CSF possesses unique and interesting characteristics among the family of hematopoietic growth factors. This chapter will summarize the current state of knowledge of the structure and function of G-CSF and its receptor.

I.1 Identification of G-CSF and its gene

The identification of CSFs was made possible by cell culture assays for hematopoietic progenitor cells developed in the mid 1960s by Metcalf and his colleagues2. These in vitro systems showed that the survival, proliferation, and differentiation of immature hematopoietic cells were dependent on the continued presence of humoral factors, which was collectively termed “colony-stimulating activity” (CSA)3. Before the purification of individual factors, early sources of CSA [included media that was conditioned by stimulated cultures of normal blood or certain tumour cells.]


2. Bradley TR, Robinson W, Metcalf D. Colony production in vitro by normal polycythaemic and anaemic bone marrow. Nature. 1967;214:511.

3. Demetri GD, Griffin JD. Granulocyte colony-stimulating factor and its receptor. Blood. 1991;78:2791-2808.

G-CSF possesses unique and interesting characteristics among the family of hematopoietic growth factors. This review will summarize the current state of knowledge of the structure and function of G-CSF and its receptor.

IDENTIFICATION OF G-CSF

The identification of CSFs was made possible by the cell culture assays for hematopoietic progenitor cells, which were developed in the mid 1960s independently by Metcalf, Sachs, and their colleagues. These in vitro systems showed that the survival, proliferation, and differentiation of immature hematopoietic cells were dependent on the continued presence of humoral factors, which were collectively termed “colony-stimulating activity” (CSA). Before the purification of individual factors, early sources of CSA included media conditioned by culture with stimulated normal blood or splenic leukocytes, placenta, or certain tumor cells1-5.


1. Metcalf D: The granulocyte-macrophage colony-stimulating factors. Science 229:16, 1985

2. Metcalf D: The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells. Nature 339:27, 1989

3. Sachs L The molecular control of blood cell development. Science 238:1374, 1987

4. Quesenberry P, Levitt L Hematopoietic stem cells. N Engl J Med 301:755,1979

5. Golde D, Cline M: Regulation of granulopoiesis. N Engl J Med 291:1388,1974

Anmerkungen

At the end of the page the source is given. Nevertheless nothing has been marked as a citation and it is not clear to the reader that even the end of the previous section is taken verbatim from the source.

Sichter
(Graf Isolan), Hindemith

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