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| Untersuchte Arbeit: Seite: 16, Zeilen: 9-16 |
Quelle: Avalos 1996 Seite(n): 761, Zeilen: l.col: 20ff |
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| The immature neutrophils that arise from bone marrow follow a process that involves proliferation, differentiation along the granulocyte lineage and terminal maturation into functional neutrophils. Many other hematopoietic growth factors like stem cell factor (SCF), IL-3, GM-CSF, IL-6, have been shown to be positive regulators of granulopoiesis and act at different stages of myeloid cell development. But, G-CSF is unique among the regulators of granulopoiesis, because it not only stimulates the proliferation but also potently induces the terminal maturation of myeloid progenitor cells to neutrophilic granulocytes1.
1. Basu S, Dunn A, Ward A. G-CSF: function and modes of action (Review). Int J Mol Med. 2002;10:3-10. |
Mature neutrophils arise from bone marrow (BM) stem cells following a process involving proliferation, commitment to differentiation along the granulocyte lineage, and terminal maturation.5 Several hematopoietic growth factors including stem cell factor (SCF), interleukin-3 (IL-3), granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-6, and G-CSF have been shown to be positive regulators of granulopoiesis and act at different stages of myeloid cell development.6,7 [...] G-CSF is unique among the regulators of granulopoiesis in that it not only stimulates the proliferation but also potently induces the terminal maturation of myeloid progenitor cells to neutrophilic granulocytes.
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