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Typus
BauernOpfer
Bearbeiter
Hindemith
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 22, Zeilen: 15-24
Quelle: Quinn and Gauss 2004
Seite(n): 761, Zeilen: l.col: 23ff
In general, the best characterized plasma membrane oxidase is the phagocytic NADPH oxidase, a multicomponent enzyme composed of four oxidase-specific proteins (p22phox, p47phox, p67phox, and gp91phox) and a GTPase (Rac1/2). One other oxidase-specific protein (p40phox) and a second GTPase (Rap1A) have also been shown to play roles in regulating oxidase activity; however, their specific functions are still not well understood60. Originally, the nomenclature for the various components differed throughout the literature (Table 1); however, the generally accepted nomenclature for the phagocyte oxidase specific components now includes the suffix phox, which refers to phagocyte oxidase61. The only one exception is gp91phox, which has also been named NADPH oxidase 2 (Nox2)62.

60. Quinn MT, Gauss KA. Structure and regulation of the neutrophil respiratory burst oxidase: comparison with nonphagocyte oxidases. J Leukoc Biol. 2004;76:760-781.

61. Babior BM. NADPH oxidase. Current Opinion in Immunology. 2004;16:42-47.

62. Lambeth JD, Cheng G, Arnold RS, Edens WA. Novel homologs of gp91phox. Trends Biochem Sci. 2000;25:459-461.

It is now generally accepted that the core NADPH oxidase enzyme is composed of four oxidase-specific proteins (p22phox, p47phox, p67phox, and gp91phox) and a GTPase (Rac1/2). One other oxidase-specific protein (p40phox) and a second GTPase (Rap1A) have also been shown to play roles in regulating oxidase activity; however, their specific functions are still not well understood. Originally, the nomenclature for the various components differed throughout the literature; however, the generally accepted nomenclature for the phagocyte oxidasespecific components now includes the suffix phox, which refers to phagocyte oxidase [10]. The one exception is gp91phox, which has also been named NADPH oxidase 2 (Nox2) [11].

10. Babior, B. M. (1991) The respiratory burst oxidase and the molecular basis of chronic granulomatous disease. Am. J. Hematol. 37, 263–266.

11. Lambeth, J. D., Cheng, G., Arnold, R. S., Edens, W. A. (2000) Novel homologs of gp91phox. Trends Biochem. Sci. 25, 459–461.

Anmerkungen

The source is mentioned somewhere in the middle, but it is not clear to the reader that the entire passage is taken from it, including a reference to the literature.

Sichter
(Hindemith), Graf Isolan

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