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| [1.] Br/Fragment 014 03 - Diskussion Zuletzt bearbeitet: 2016-05-21 17:53:47 Schumann | Br, Fragment, Gesichtet, KomplettPlagiat, SMWFragment, Schutzlevel sysop, Spruston 2008 |
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| Untersuchte Arbeit: Seite: 14, Zeilen: 3-20 |
Quelle: Spruston 2008 Seite(n): 206, 208, Zeilen: 206:li.Sp.18-21.re.Sp. 7-17; 208:re.Sp. 26-38 |
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| The long axon of each pyramidal neuron typically emanates from the base of the soma and branches profusely, making excitatory glutamatergic synaptic contacts along its length. The dendritic tree of a pyramidal neuron has two distinct domains: the basal and apical dendrites, which descend from the base and the apex of the soma, respectively. All pyramidal neurons have several, relatively short basal dendrites. Usually one large apical dendrite connects the soma to a tuft of dendrites. This main apical dendrite bifurcates before giving rise to the tuft at a variable distance from the soma. In some cases the resulting dendrites each bifurcate again. Oblique apical dendrites emanate from the main apical dendrite at various angles.
The distinct morphologies of basal and apical dendrites suggest that inputs to these domains might be integrated differently. Furthermore, different dendritic domain receive distinct synaptic inputs, for instance, CA1 neurons receive input to the distal tuft from the entorhinal cortex through the perforant path and from the thalamus, whereas the remainder of the dendrites receive input from CA3 through the Schaffer collaterals. Furthermore, CA3 neurons that are distant from CA1 project primarily to apical dendrites, whereas CA3 neurons that are closer to CA1 project more heavily to basal dendrites. The functional significance of this arrangement remains mysterious. |
[Seite 206]
The lone axon of each pyramidal neuron typically emanates from the base of the soma and branches profusely, making many excitatory glutamatergic synaptic contacts along its length. [...] The dendritic tree of a pyramidal neuron has two distinct domains: the basal and the apical dendrites, which descend from the base and the apex of the soma, respectively (FIG. 1a). All pyramidal neurons have several relatively short basal dendrites. Usually, one large apical dendrite connects the soma to a tuft of dendrites. This main apical dendrite bifurcates before giving rise to the tuft at a variable distance from the soma. In some cases the resulting ‘twin’ apical dendrites each bifurcate again4–6. Oblique apical dendrites emanate from the main apical dendrite at various angles. [Seite 208] The distinct morphologies of basal and apical dendrites suggest that inputs to these domains might be integrated differently. Furthermore, different dendritic domains receive distinct synaptic inputs. For example, CA1 neurons receive input to the distal tuft from the entorhinal cortex through the perforant path and from the thalamus, whereas the remainder of the dendrites receive input from CA3 through the Schaffer collaterals. Furthermore, CA3 neurons that are distant from CA1 project primarily to apical dendrites, whereas CA3 neurons that are closer to CA1 project more heavily to basal dendrites27,28. The functional significance of this arrangement remains mysterious. 4. Bannister, N. J. & Larkman, A. U. Dendritic morphology of CA1 pyramidal neurones from the rat hippocampus: I. Branching patterns. J. Comp. Neurol. 360, 150–160 (1995). 5. Ito, M., Kato, M. & Kawabata, M. Premature bifurcation of the apical dendritic trunk of vibrissaresponding pyramidal neurones of X‑irradiated rat neocortex. J. Physiol. 512, 543–553 (1998). 6. DeFelipe, J. & Farinas, I. The pyramidal neuron of the cerebral cortex: morphological and chemical characteristics of the synaptic inputs. Prog. Neurobiol. 39, 563–607 (1992). 27. Ishizuka, N., Weber, J. & Amaral, D. G. Organization of intrahippocampal projections originating from CA3 pyramidal cells in the rat. J. Comp. Neurol. 295, 580–623 (1990). 28. Li, X. G., Somogyi, P., Ylinen, A. & Buzsaki, G. The hippocampal CA3 network: an in vivo intracellular labeling study. J. Comp. Neurol. 339, 181–208 (1994). |
Ohne Hinweis auf eine Übernahme. "long" statt "lone", "instance" statt "example" sind die einzigen "substantiellen" Änderungen, welche Br hier durchführt. |
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Letzte Bearbeitung dieser Seite: durch Benutzer:Schumann, Zeitstempel: 20160521175434