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[1.] Br/Fragment 017 05 - Diskussion
Zuletzt bearbeitet: 2016-05-21 18:09:04 Schumann
BauernOpfer, Br, Fragment, Gesichtet, Lynch und Schubert 1980, SMWFragment, Schutzlevel sysop

Typus
BauernOpfer
Bearbeiter
Graf Isolan
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 17, Zeilen: 5-11, 13-17
Quelle: Lynch und Schubert 1980
Seite(n): 1, 3, Zeilen: 1:2-11; 3:1-7
Among the spectrum of experimental strategies used by neurobiologists to promote the understanding of brain function, the in vitro systems offer a number of opportunities. In in vitro studies a large number of well-defined independent variables can be readily introduced. The dependent variables are usually more accessible to measurement and can be monitored with a variety of techniques than in the case of in vivo. The interference from peripheral factors, which are more common in in vivo is greatly reduced (Lynch, 1980).

[In our studies we are performing in vitro experiments with slices from hippocampus.] The main reason is because it contains a considerable proportion of the major fibre projections and their attendant synaptic domains can be prepared. Most of the major intrinsic and extrinsic hippocampal fibre systems are organized according to a lamellar plan in which they travel at right angles to the longitudinal axis of the structure (Anderson et al., 1971, Blackstad et al., 1970).


• Andersen P, Bliss TV, Lomo T, Olsen LI, Skrede KK (1969) Lamellar organization of hippocampal excitatory pathways. Acta Physiol Scand 76:4A-5.

• Blackstad TW, Brink K, Hem J, Jeune B (1970) Distribution of hippocampal mossy fibers in the rat. An experimental study with silver impregnation methods. J Comp Neurol.138:433-49.

• Lynch G, Schubert P (1980) The use of in vitro brain slices for multidisciplinary studies of synaptic function. Annu Rev Neurosci 3:1-22.

[Seite 1]

Among the spectrum of experimental strategies used by neurobiologists to promote the understanding of brain function, the in vitro approach has found a wide and constantly growing application. In vitro systems offer a number of opportunities not available with more conventional techniques:

1. a large number of well-defined independent variables can be readily introduced,

2. dependent variables are usually more accessible to measurement and can be monitored with a greater variety of techniques than is the case in vivo,

3. interference from peripheral factors, which often compromises in vivo experiments, is greatly reduced.

[Seite 3]

Finally, and most important, hippocampal slices that contain a considerable proportion of the major fiber projections and their attendant synaptic domains can be prepared. Most of the major intrinsic and extrinsic hippocampal fiber systems are organized according to a "lamellar" plan in which they travel at right angles to the longitudinal axis of the structure (Andersen et al 1971 b, Blackstad et al 1970).


Andersen, P., Bliss, T. V. P., Skrede, K. K. 1971 b. Lamellar organization of hippocampal excitatory pathways. Exp. Brain Res. 13:222-38

Blackstad, T. W., Brink, K., Hem, J., Jeune, B. 1970. Distribution of hippocampal mossy fibers in the rat: An experimental study with silver impregnation methods. J. Camp. Neural. 138;433-50

Anmerkungen

Art und Umfang der Übernahme bleiben ungekennzeichnet.

Sichter
(Graf Isolan) Schumann

[2.] Br/Fragment 017 17 - Diskussion
Zuletzt bearbeitet: 2016-05-21 18:10:28 Schumann
Br, Fragment, Gesichtet, SMWFragment, Sajikumar 2005, Schutzlevel sysop, Verschleierung

Typus
Verschleierung
Bearbeiter
Graf Isolan
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Untersuchte Arbeit:
Seite: 17, Zeilen: 17-25
Quelle: Sajikumar 2005
Seite(n): 16, Zeilen: 1-2, 4-8, 13-17
The hippocampal slice offers a variety of opportunities like visual control of electrode placement, possibility to direct electrodes to known parts of a given cell. For example an electrode may be placed in the apical or basal dendritic tree of pyramidal cells at known distances from the soma to record the activity of a small population of synapses. Furthermore in the slice preparation, the ability to change the concentration of interesting molecules at will provides a good experimental control of the preparation. In addition to the temperature and oxygen concentration, the pH, ionic concentration and hormonal levels can be changed at will. Brain slices offer a variety of novel opportunities, the most obvious being visual inspection. [...] This allows visual control of electrode placement. It is also possible to direct electrodes to known parts of a given cell. For example, in the hippocampus, an electrode may be placed in the apical or basal dendritic tree of pyramidal cells at known distances from the soma to record the activity of a small group of synapses. [...] Furthermore, in the slice preparation the influence of the blood brain barrier is removed. The ability to change the tissue concentration of interesting molecules at will provides good experimental control of the preparation. In addition to the temperature and oxygen concentration, the pH, ionic concentration and hormonal levels can be changed at will.
Anmerkungen

Ohne Hinweis auf eine Übernahme.

Sichter
(Graf Isolan) Schumann


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