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[1.] Br/Fragment 075 16 - Diskussion
Zuletzt bearbeitet: 2016-05-21 17:51:11 Schumann
Br, Fragment, Gesichtet, Martin und Kosik 2002, SMWFragment, Schutzlevel sysop, Verschleierung

Typus
Verschleierung
Bearbeiter
Graf Isolan
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 75, Zeilen: 16-21, 24-26
Quelle: Martin und Kosik 2002
Seite(n): 815, Zeilen: re.Sp. 34-45
Persistently active kinases meet several criteria for the tag, as they allow a synapse to remember previous activity in a spatially restricted and reversible manner. Calcium/calmodulin-dependent protein kinase II (CaMKII), which becomes autonomously and persistently active by autophosphorylation, has been activated by synaptic stimulation, meets an identity of the tag. [...] The atypical protein kinase C known as protein kinase M Zeta (PKMζ), the persistent activity of which requires protein synthesis, has been shown to be another possible candidate. Kinases. Persistently active kinases meet several of the criteria for a tag, as they allow a synapse to ‘remember’ previous activity in a spatially restricted and reversible manner. Calcium/calmodulin-dependent protein kinase II (CaMKII), which becomes autonomously and persistently active by autophosphorylation, has been shown to be activated by, and necessary for, long-term plasticity and long-term memory8. The atypical protein kinase C known as protein kinase Mζ (PKM-ζ), the persistent activity of which requires protein synthesis9, has been shown to be both necessary and sufficient for the maintenance of L-LTP in the hippocampus10.

8. Lisman, J., Schulman, H. & Cline, H. The molecular basis of CaMKII function in synaptic and behavioural memory. Nature Rev. Neurosci. 3, 175–190 (2002).

9. Osten, P., Valsamis, L., Harris, A. & Sacktor, T. C. Protein synthesis-dependent formation of protein kinase Mζ in longterm potentiation. J. Neurosci. 16, 2444–2451 (1996).

10. Ling, D. S. et al. Protein kinase Mζ is necessary and sufficient for LTP maintenance. Nature Neurosci. 5, 295–296 (2002).

Anmerkungen

Im Diskussionsteil. Ohne Hinweis auf eine Übernahme.

Sichter
(Graf Isolan) Schumann

[2.] Br/Fragment 075 21 - Diskussion
Zuletzt bearbeitet: 2016-05-04 21:37:56 WiseWoman
Br, Fragment, Gangadharan 2006, Gesichtet, SMWFragment, Schutzlevel sysop, Verschleierung

Typus
Verschleierung
Bearbeiter
Graf Isolan
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 75, Zeilen: 21-26
Quelle: Gangadharan 2006
Seite(n): 37, 90, Zeilen: 37:19-23; 90:5-8.(9-10)
The CaMKII holoenzymes were shown to be capable of associating with one another in response to Ca2+ [sic].Therefore CaMKII may form a scaffold that, in combination with other synaptic proteins, recruits and localizes additional proteins to the postsynaptic density (Hudmon et al., 2005). The atypical protein kinase C known as protein kinase M Zeta (PKMζ), the persistent activity of which requires protein synthesis, has been shown to be another possible candidate. But recently it has [been found that PKMζ is the first LTP specific plasticity-related protein (PRP) and not a tag molecule in apical CA1 branches (Sajikumar et al., 2005) but in basal dendrites the coactivation of PKA or PKM Zeta is required for synaptic tagging (Sajikumar et al., 2007).]

• Hudmon A, Lebel E, Roy H, Sik A, Schulman H, Waxham MN, De Koninck P (2005) A mechanism for Ca2+/calmodulin-dependent protein kinase II clustering at synaptic and nonsynaptic sites based on self-association. J Neurosci 25:6971-83.

• Sajikumar S, Navakkode S, Frey JU (2005) Protein synthesis-dependent long-term functional plasticity: Methods and techniques. Curr Opin Neurobiol 15:607-613.

• Sajikumar S, Navakkode S, Sacktor TC, Frey JU (2005b) Synaptic tagging and cross tagging: the role of protein kinase M zeta in maintaining long-term potentiation but not long-term depression. J Neurosci 25:5750-5756.

[page 37]

The atypical protein kinase C known as protein kinase Mζ (PKMζ), the persistent activity of which requires protein synthesis, has been shown to be another possible candidate. But recently we could identify PKMæ as the first LTP specific plasticity related protein, not a tag molecule (Sajikumar et al., 2005b).

[page 90]

More recently Hudmon et al showed that CaMKII holoenzymes were shown to be capable of associating with one another (or self-associate) in response to Ca2+ stimulation. Therefore CaMKII may form a scaffold that, in combination with other synaptic proteins, recruits and localizes additional proteins to the postsynaptic density. They also discussed the potential function of CaMKII self-association as a ´tag´ of synaptic activity (Hudmon et al., 2005). [...]


74. Hudmon A, Lebel E, Roy H, Sik A, Schulman H, Waxham MN, De Koninck P (2005) A mechanism for Ca2+/calmodulin-dependent protein kinase II clustering at synaptic and nonsynaptic sites based on self-association. J Neurosci 25: 6971-6983.

139. Sajikumar S, Navakkode S, Frey JU (2005a) Protein synthesis-dependent long-term functional plasticity: methods and techniques. Curr Opin Neurobiol ..

140. Sajikumar S, Navakkode S, Sacktor TC, Frey JU (2005b) Synaptic tagging and cross-tagging: the role of protein kinase Mzeta in maintaining long-term potentiation but not long-term depression. J Neurosci 25: 5750-5756.

Anmerkungen

From the final part - "Discussion" - of the thesis, Not marked as a citation.

Sichter
(Graf Isolan) Schumann


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