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[1.] Br/Fragment 077 01 - Diskussion
Zuletzt bearbeitet: 2016-05-21 17:49:30 Schumann
Br, Fragment, Gesichtet, Martin und Kosik 2002, SMWFragment, Schutzlevel sysop, Verschleierung

Typus
Verschleierung
Bearbeiter
Graf Isolan
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 77, Zeilen: 1-10
Quelle: Martin und Kosik 2002
Seite(n): 815, Zeilen: re.Sp. 8-11, 14-22, 25-31
[The stimuli that can produce a synaptic tag are not necessarily sufficient to activate protein synthesis, and are therefore frequently considered to be sub]threshold for long-term plasticity. Such stimuli induce a host of changes at the synapse and any number of these changes could potentially serve as a tag. Many of these changes are related to the activity and strength of the synapse, such as rapid addition of AMPA receptors to ionotropic glutamate receptor clusters (Shi et al., 1999), the lateral mobility of NMDA receptors between synaptic and extra-synaptic sites (Westbrook et al., 2002) etc. Such events could serve as localized traces of previous synaptic activity that are able to produce synaptic strengthening on their own with in [sic] a limited time period. However, to function as synaptic tags, they would need to be able to interact with cell wide events to produce local and persistent increase in synaptic efficacy.

• Shi SH, Hayashi Y, Petralia RS, Zaman SH, Wenthold RJ, Svoboda K, Malinow R (1999) Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation. Science 284:1811-6.

The stimuli that can produce a synaptic tag are not necessarily sufficient to activate transcription, and are therefore frequently considered to be subthreshold for long-term plasticity. [...] Such stimuli induce a host of changes at the synapse, and any number of these changes could potentially serve as a tag. Many of these changes are related to the activity and strength of the synapse, such as the rapid addition of AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors to ionotropic glutamate receptor clusters4, the lateral mobility of NMDA (N-methyl-D-aspartate) receptors between synaptic and extrasynaptic sites5, [HOMER-mediated insertion of the metabotropic glutamate receptor mGluR5 into the membrane6, and palmitate cycling on postsynaptic density protein 95 (PSD95; REF. 7)]. Such events could serve as localized traces of previous synaptic activity that are able to produce synaptic strengthening on their own within a limited time period. However, to function as synaptic tags, they would need to be able to interact with cell-wide events to produce local and persistent increases in synaptic efficacy.

4. Shi, S. H. et al. Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation. Science 284, 1811–1816 (1999).

5. Tovar, K. R. & Westbrook, G. L. Mobile NMDA receptors at hippocampal synapses. Neuron 34, 255–264 (2002).

[6. Ango, F. et al. Homer-dependent cell surface expression of metabotropic glutamate receptor type 5 in neurons. Mol. Cell. Neurosci. 20, 323–329 (2002).

7. El-Husseini, A. E. et al. Synaptic strength regulated by palmitate cycling on PSD-95. Cell 108, 849–863 (2002).]

Anmerkungen

Im Diskussionsteil. Ohne Hinweis auf eine Übernahme.

Für die Quelle "(Westbrook et al., 2002)" findet sich im Literaturverzeichnis von Br keine Referenz.

Sichter
(Graf Isolan) Schumann


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