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Graf Isolan
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Untersuchte Arbeit:
Seite: 15, Zeilen: 13-26
Quelle: Golding et al 1999
Seite(n): 8789, 8797, Zeilen: 8789:re.Sp. 9-11.24-27; 8797:li.Sp. 6-19
(Wong et al., 1979; Benardo et al., 1982; Wong and Stewart, 1992; Andreasen and Lambert, 1995; Kamondi et al., 1998). The restriction of calcium spike initiation to the dendrites is likely the result of strong activation of potassium channels in the soma and proximal dendrites by sodium-dependent action potentials. Calcium spikes appear to detect specific spatial and temporal combinations of synaptic input and signal these events to the synaptic target of neuron through the generation of a distinctive burst of action potential out put [sic] (Lisman, 1997).

Calcium spikes may serve as a powerful regulator of synaptic plasticity, because they would likely mediate a substantial influx of calcium through voltage-gated calcium channels. Furthermore, the prolonged depolarizations mediated by calcium spikes would relieve the voltage-dependent block on NMDA receptors and induce additional calcium influx. Calcium spikes could thus serve as a robust cellular mechanism by which synaptic inputs conveying temporally correlated information [might be selectively reinforced.]


• Andreasen M, Lambert JD (1995) The excitability of CA1 pyramidal cell dendrites is modulated by a local Ca (2+)-dependent K(+)-conductance. Brain Res. 698:193-203.

• Benardo LS, Prince DA (1982) Dopamine modulates a Ca2+-activated potassium conductance in mammalian hippocampal pyramidal cells. Nature 297:76-79.

• Kamondi A, Acsády L, Buzsáki G (1998) Dendritic spikes are enhanced by cooperative network activity in the intact hippocampus. J Neurosci 18:3919-28.

• Lisman, J. (1997) Bursts as a unit of neural information: making unreliable synapses reliable. Trends In Neuroscience 20:38-43.

• Wong RKS, Prince DA, Basbaum AI (1979) Intradendritic recordings from hippocampal neurons. Proc Natl Acad Sci USA 76:986-990.

• Wong RK, Stewart M (1992) Different firing patterns generated in dendrites and somata of CA1 pyramidal neurones in guinea-pig hippocampus. J Physiol 457:675-87.

[Seite 8789]

(Wong et al., 1979; Benardo et al., 1982; Wong and Stewart, 1992; Andreasen and Lambert, 1995; Kamondi et al., 1998).

[...] The restriction of calcium spike initiation to the dendrites is likely the result of strong activation of potassium channels in the soma and proximal dendrites by sodium-dependent action potentials.

[Seite 8797]

Thus, in a variety of brain areas, calcium spikes appear to detect specific spatial and temporal combinations of synaptic input and signal these events to the synaptic targets of the neuron through the generation of a distinctive burst of action potential output (Lisman, 1997).

Calcium spikes may serve as powerful regulators of synaptic plasticity, because they would likely mediate a substantial influx of calcium through voltage-gated calcium channels. Furthermore, the prolonged depolarizations mediated by calcium spikes would relieve the voltage-dependent block on NMDA receptors and induce additional calcium influx. Calcium spikes could thus serve as a robust cellular mechanism by which synaptic inputs conveying temporally correlated information might be selectively reinforced.


Andreasen M, Lambert JD (1995) Regenerative properties of pyramidal cell dendrites in area CA1 of the rat hippocampus. J Physiol (Lond) 483:421– 441.

Benardo LS, Masukawa LM, Prince DA (1982) Electrophysiology of isolated hippocampal pyramidal dendrites. J Neurosci 2:1614 –1622.

Kamondi A, Acsady L, Buzsa´ki G (1998) Dendritic spikes are enhanced by cooperative network activity in the intact hippocampus. J Neurosci 18:3919 –3928.

Lisman JE (1997) Bursts as a unit of neural information: making unreliable synapses reliable. Trends Neurosci 20:38–43.

Wong RK, Prince DA, Basbaum AI (1979) Intradendritic recordings from hippocampal neurons. Proc Natl Acad Sci USA 76:986 –990.

Wong RKS, Stewart M (1992) Different firing patterns generated in dendrites and somata of CA1 pyramidal neurones in guinea-pig hippocampus. J Physiol (Lond) 457:675– 687.

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