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| Untersuchte Arbeit: Seite: 17, Zeilen: 17-25 |
Quelle: Sajikumar 2005 Seite(n): 16, Zeilen: 1-2, 4-8, 13-17 |
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| The hippocampal slice offers a variety of opportunities like visual control of electrode placement, possibility to direct electrodes to known parts of a given cell. For example an electrode may be placed in the apical or basal dendritic tree of pyramidal cells at known distances from the soma to record the activity of a small population of synapses. Furthermore in the slice preparation, the ability to change the concentration of interesting molecules at will provides a good experimental control of the preparation. In addition to the temperature and oxygen concentration, the pH, ionic concentration and hormonal levels can be changed at will. | Brain slices offer a variety of novel opportunities, the most obvious being visual inspection. [...] This allows visual control of electrode placement. It is also possible to direct electrodes to known parts of a given cell. For example, in the hippocampus, an electrode may be placed in the apical or basal dendritic tree of pyramidal cells at known distances from the soma to record the activity of a small group of synapses. [...] Furthermore, in the slice preparation the influence of the blood brain barrier is removed. The ability to change the tissue concentration of interesting molecules at will provides good experimental control of the preparation. In addition to the temperature and oxygen concentration, the pH, ionic concentration and hormonal levels can be changed at will. |
Ohne Hinweis auf eine Übernahme. |
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