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Bearbeiter
Graf Isolan
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Untersuchte Arbeit:
Seite: 75, Zeilen: 21-26
Quelle: Gangadharan 2006
Seite(n): 37, 90, Zeilen: 37:19-23; 90:5-8.(9-10)
The CaMKII holoenzymes were shown to be capable of associating with one another in response to Ca2+ [sic].Therefore CaMKII may form a scaffold that, in combination with other synaptic proteins, recruits and localizes additional proteins to the postsynaptic density (Hudmon et al., 2005). The atypical protein kinase C known as protein kinase M Zeta (PKMζ), the persistent activity of which requires protein synthesis, has been shown to be another possible candidate. But recently it has [been found that PKMζ is the first LTP specific plasticity-related protein (PRP) and not a tag molecule in apical CA1 branches (Sajikumar et al., 2005) but in basal dendrites the coactivation of PKA or PKM Zeta is required for synaptic tagging (Sajikumar et al., 2007).]

• Hudmon A, Lebel E, Roy H, Sik A, Schulman H, Waxham MN, De Koninck P (2005) A mechanism for Ca2+/calmodulin-dependent protein kinase II clustering at synaptic and nonsynaptic sites based on self-association. J Neurosci 25:6971-83.

• Sajikumar S, Navakkode S, Frey JU (2005) Protein synthesis-dependent long-term functional plasticity: Methods and techniques. Curr Opin Neurobiol 15:607-613.

• Sajikumar S, Navakkode S, Sacktor TC, Frey JU (2005b) Synaptic tagging and cross tagging: the role of protein kinase M zeta in maintaining long-term potentiation but not long-term depression. J Neurosci 25:5750-5756.

[page 37]

The atypical protein kinase C known as protein kinase Mζ (PKMζ), the persistent activity of which requires protein synthesis, has been shown to be another possible candidate. But recently we could identify PKMæ as the first LTP specific plasticity related protein, not a tag molecule (Sajikumar et al., 2005b).

[page 90]

More recently Hudmon et al showed that CaMKII holoenzymes were shown to be capable of associating with one another (or self-associate) in response to Ca2+ stimulation. Therefore CaMKII may form a scaffold that, in combination with other synaptic proteins, recruits and localizes additional proteins to the postsynaptic density. They also discussed the potential function of CaMKII self-association as a ´tag´ of synaptic activity (Hudmon et al., 2005). [...]


74. Hudmon A, Lebel E, Roy H, Sik A, Schulman H, Waxham MN, De Koninck P (2005) A mechanism for Ca2+/calmodulin-dependent protein kinase II clustering at synaptic and nonsynaptic sites based on self-association. J Neurosci 25: 6971-6983.

139. Sajikumar S, Navakkode S, Frey JU (2005a) Protein synthesis-dependent long-term functional plasticity: methods and techniques. Curr Opin Neurobiol ..

140. Sajikumar S, Navakkode S, Sacktor TC, Frey JU (2005b) Synaptic tagging and cross-tagging: the role of protein kinase Mzeta in maintaining long-term potentiation but not long-term depression. J Neurosci 25: 5750-5756.

Anmerkungen

From the final part - "Discussion" - of the thesis, Not marked as a citation.

Sichter
(Graf Isolan) Schumann

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