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| Untersuchte Arbeit: Seite: 15, Zeilen: 1-11 |
Quelle: El Harrak 2009 Seite(n): 6, Zeilen: 6-16 |
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| Mechanical stimulation, for example, by stroking of the cortical surface with a blunt instrument, a falling weight or even lightly tapping the cortex also initiates SD (Leao [sic], 1944). More recent studies have achieved more reliable and reproducible induction of CSD by rapidly inserting and retracting hypodermic steel needles (Kaube and Goadsby, 1994; Lambert et al., 1999; Ebersberger et al., 2001). However, one of the most common models of SD initiation is KCl application to the neuronal tissues (Wernsmann et al., 2006; Dehbandi et al., 2008). This model has been proven to be the most reliable stimulus leading to reproducible events on earlier investigations (Martins-Ferreira et al., 2000; Bradley et al., 2001). Changes in extracellular K+ concentration might be involved in such pathophysiological processes in human brain tissue (Mayevsky et al., 1996; Nicholson & Sykova, 1998). | Mechanical stimulation, for example, by stroking of the cortical surface with a blunt instrument, a falling weight or even lightly tapping the cortex also initiates SD (Lea˜o [sic], 1944). More recent studies have achieved more reliable and reproducible induction of SD by rapidly inserting and retracting hypodermic steel needles (Lambert et al., 1999; Ebersberger et al., 2001). However, the most common models of SD initiation is KCl application (Wernsmann et al., 2006; Dehbandi et al., 2008). This model has been shown to be the most reliable stimulus leading to reproducible events on earlier occasions in both non-imaging and imaging studies (Bradley et al., 2001). In any case, changes in extracellular K+ concentration themselves might be involved in such pathophysiological processes in human brain tissue (Mayevsky et al., 1996; Nicholson and Sykova, 1998). |
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