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| Untersuchte Arbeit: Seite: 23, Zeilen: 1-7 |
Quelle: Wright 2005 Seite(n): 63, Zeilen: figure |
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Figure 4: Collectin receptors. Surfactant protein A (SP-A) and SP-D potentially bind several receptors, including SP-R210, Toll-like receptor 2 (TLR2), TLR4, signal-inhibitory regulatory protein-α (SIRP-α) and CD91-calreticulin. SP-A binds SIRP-α and inhibits production of inflammatory mediators. In contrast, when SP-A is bound to a pathogen or cellular debris, its collagen-like region is bound to CD91-calreticulin and induces inflammatory-mediator production. Nuclear factor κB, (NF-κB); protein kinase C (PKC); SRC homology 2 (SH2)-domain-containing protein tyrosine phosphatase 1 (SHP1) (adapted from Wright, 2005). Wright JR. Immunoregulatory functions of surfactant proteins. Nat Rev Immunol. 2005 Jan; 5 (1): 58-68. Review. |
Figure 4 Collectin receptors. Surfactant protein A (SP-A) and SP-D potentially bind several receptors, including SP-R210, Toll-like receptor 2 (TLR2), TLR4, signal-inhibitory regulatory protein-α (SIRP-α) and CD91-calreticulin. SP-A binds SIRP-α and inhibits production of inflammatory mediators. By contrast, when SP-A is bound to a pathogen or cellular debris, its collagen-like region is bound to CD91-calreticulin and induces inflammatory-mediator production. NF-κB, nuclear factor-κB; PKC, protein kinase C; SHP1, SRC homology 2 (SH2)-domain-containing protein tyrosine phosphatase 1. |
The source is given, but it is not clear to the reader that the extensive figure caption is taken literally from it. Neither is it clear that "adapted from" actually means "copied from". |
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