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| Untersuchte Arbeit: Seite: 32, Zeilen: 1-3 |
Quelle: Bluestone_Abbas_2003 Seite(n): 255, Zeilen: col. 1, lines 45-55 |
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| [This contact-dependent mechanism of suppression has been shown most convincingly by CD4+CD25+ natural Treg cells employed in in vitro models of suppression, whereas cytokine-mediated suppression has been best established for peripheral adaptive Treg] cells in vivo. However, the adaptive Treg cell subset, although it suppresses in a cytokine-dependent manner, might still require direct cell-cell contact to initiate the suppressive cascade.
Figure 6: Two classes of regulatory T cells can be envisioned. a In this hypothetical model, the natural regulatory T (Treg) cells (blue) suppress immune response in a contact-dependent manner and function in general homeostasis to block the actions of autoimmune T cells (red) in noninflammatory settings. b The adaptive Treg cell subset enhances the robust nature of suppression in an inflammatory milieu. Importantly, adaptive Treg cells can develop either CD4+CD25+ natural Treg cells (blue striped) or by altering the activity of T helper (TH) cells (red striped). APC, antigen presenting cell; interleukin (IL)-10, transforming growth factor (TGF)-β, regulatory T cell (Treg) (adapted from Bluestone and Abbas, 2003). |
This contact-dependent mechanism of suppression has been shown most convincingly by CD4+CD25+ natural TReg cells tested in in vitro models of suppression, whereas cytokine-mediated suppression has been best established for peripheral adaptive TReg cells in vivo33. However, the adaptive TReg-cell subset, although it suppresses in a cytokine-dependent manner, might still require direct cell-cell contact to initiate the suppressive cascade.
Figure 1 Two classes of regulatory T cells can be envisioned. a In this hypothetical model, the natural regulatory T (TReg) cells (blue) suppress immune responses in a contact-dependent manner and function in general homeostasis to block the actions of autoimmune T cells (red) in non-inflammatory settings. b The adaptive TReg-cell subset enhances the robust nature of suppression in an inflammatory milieu. Importantly, adaptive TReg cells can develop either from CD4+CD25+ natural TReg cells (blue striped) or by altering the activity of T helper (TH) cells (red striped). APC, antigen-presenting cell; IL-10, interleukin-10; TGF-β, transforming growth factor-β. 33. Bach, J. F. & Chatenoud, L. Tolerance to islet autoantigens and type I diabetes. Annu. Rev. Immunol. 19, 131–161 (2001). |
At the end of the caption one finds "adapted from Bluestone and Abbas, 2003". |
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