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Nierenfunktion Kinase-defizienter Mäuse

von Dr. Diana Sandulache

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[1.] Dsa/Fragment 038 00 - Diskussion
Zuletzt bearbeitet: 2016-08-18 20:38:52 WiseWoman
Amorim et al 2004, Dsa, Fragment, Gesichtet, KomplettPlagiat, SMWFragment, Schutzlevel sysop

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Quelle: Amorim et al 2004
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Dsa 038a diss.png

Figure nr. 8 - Schematic drawing of cell signalling mechanisms of luminal (V1 receptors) and basolateral (V2 receptors) action of arginine vasopressin (AVP).

The role of V1 receptors and their signalling are derived from the present studies. The role of V2 receptors in ROMK channel stimulation is based on the studies of Cassola, Giebisch and Wang.

Dsa 038a source.png

Fig. 7. Schematic drawing of cell signaling mechanisms of luminal (V1 receptors) and basolateral (V2 receptors) action of arginine vasopressin (AVP). The role of V1 receptors and their signaling are derived from the present studies. The role of V2 receptors in ROMK channel stimulation is based on the studies of Cassola, Giebisch, and Wang [6].


6. CASSOLA AC, GIEBISCH G, WANG W: Vasopressin increases density of apical low-conductance K+ channels in rat CCD. Am J Physiol Renal Fluid Electrolyte Physiol 264:F502–F509, 1993

Anmerkungen

The source is not mentioned.

Note that no paper of Cassola et al. is listed in the bibliography.

Sichter
(Hindemith), WiseWoman

[2.] Dsa/Fragment 038 01 - Diskussion
Zuletzt bearbeitet: 2016-08-06 20:25:03 WiseWoman
Boini 2006, Dsa, Fragment, Gesichtet, KomplettPlagiat, SMWFragment, Schutzlevel sysop

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Patch-clamp studies on rat CCDs found no measurable effect of acute aldosterone administration on K+ channel number, open probability, or conductance (Palmer LG. et al., (1994) Am J Physiol). However, some data suggested that aldosterone induces renal K+ secretion already at aldosterone concentrations that do not exhibit any measurable effect on urinary Na+ excretion (Bhargava et al., (2001) Endocrinology). Moreover, high K+ intake increases ROMK activity more efficiently in intact rats than in adrenalectomized animals, suggesting that aldosterone may have at least a permissive effect on ROMK activation (Palmer LG. et al., (1994) Am J Physiol).

Consistent with a possible role of aldosterone in ROMK regulation, recent studies in heterologous expression systems advocated a regulatory action of aldosterone-induced SGK1 on ROMK cell surface activity and abundance (Palmada M. et al., (2003) Biochem Biophys Res Commun). The regulatory role of SGK1 with regard to ROMK may be indirect via increased interaction with the Na+, H+ exchanger–regulating factor 2 (NHERF2) (Palmada M. et al., (2003) Biochem Biophys Res Commun) or direct via increased phosphorylation of ROMK at a serine residue within the canonical SGK1 consensus phosphorylation motif (Yoo D. et al., (2003) J Biol Chem).

Patch-clamp studies on rat CCDs found no measurable effect of acute aldosterone administration on K+ channel number, open probability, or conductance (Palmer et al., 1994). However, some data suggested that aldosterone induces renal K+ secretion already at aldosterone concentrations that do not exhibit any measurable effect on urinary Na+ excretion (Bhargava et al., 2001). Moreover, high K+ intake increases ROMK activity more efficiently in intact rats than in adrenalectomized animals, suggesting that aldosterone may have at least a permissive effect on ROMK activation (Palmer et al., 1994). Consistent with a possible role of aldosterone in ROMK regulation, recent studies in heterologous expression systems advocated a regulatory action of aldosterone-induced SGK1 on ROMK cell surface activity and abundance (Palmada et al., 2003, Palmada et al., 2003a). The regulatory role of SGK1 with regard to ROMK may be indirect via increased interaction with the Na+, H+ exchanger–regulating factor 2 (NHERF2) (Palmada et al., 2003, Palmada et al., 2003a) or direct via

[page 21]

increased phosphorylation of ROMK at a serine residue within the canonical SGK1 consensus phosphorylation motif (Yoo et al., 2003).

Anmerkungen

The source is not given.

Sichter
(Hindemith), WiseWoman


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