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Nierenfunktion Kinase-defizienter Mäuse

von Dr. Diana Sandulache

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[1.] Dsa/Fragment 043 00 - Diskussion
Zuletzt bearbeitet: 2016-08-26 20:45:10 Hindemith
Dsa, Fragment, Gesichtet, Montell 2005, SMWFragment, Schutzlevel sysop, Verschleierung

Typus
Verschleierung
Bearbeiter
WiseWoman
Gesichtet
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Untersuchte Arbeit:
Seite: 43, Zeilen: Figure 11
Quelle: Montell 2005
Seite(n): 2, Zeilen: Figure 1
Dsa 043a diss.jpg

Figure nr. 11 - The seven TRP subfamilies.

Representatives of the different subfamilies are indicated at the top and bottom, respectively. Several domains are indicated: ankyrin repeats (A), coiled coil domain (cc), protein kinase domain (TRPM6/7 only), transmembrane segments, and the TRP domain.

Dsa 043a source.png

Fig. 1. The seven TRP subfamilies. Representatives of the five group 1 and two group 2 subfamilies are indicated at the top and bottom, respectively. Several domains are indicated: ankyrin repeats (A), coiled coil domain (cc), protein kinase domain (TRPM6/7 only), transmembrane segments, and the TRP domain (see Fig. 2).

Anmerkungen

The text surrounding this picture is taken from Quelle:Dsa/Saparov_2007. The illustration is no longer available in the copy at the Internet Archive, but the reference in Saparov 2007 is to Montell 2005. Dsa has two references to Montell 2005 on the previous page, but they do not pertain to this illustration.

Sichter
(WiseWoman), Hindemith

[2.] Dsa/Fragment 043 01 - Diskussion
Zuletzt bearbeitet: 2016-08-27 21:21:45 WiseWoman
Dsa, Fragment, Gesichtet, KomplettPlagiat, SMWFragment, Saparov 2007, Schutzlevel sysop

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Bearbeiter
WiseWoman
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Untersuchte Arbeit:
Seite: 43, Zeilen: 1ff (entire page)
Quelle: Saparov 2007
Seite(n): 1 (online source), Zeilen: -
[Figure 11]

Figure nr. 11 - The seven TRP subfamilies.

Representatives of the different subfamilies are indicated at the top and bottom, respectively. Several domains are indicated: ankyrin repeats (A), coiled coil domain (cc), protein kinase domain (TRPM6/7 only), transmembrane segments, and the TRP domain.


TRP proteins are supposed to form 6 membrane-spanning segments whereas the pore region is formed by a hydrophilic region between S5 and S6 forms. The N- and C-termini are located intracellular. The N-terminus often contains ankyrin repeats as well as a coiled-coil domain, which are suspected to bind with other proteins or the cytoskeleton. Especially they are thought to be needed for TRP protein interaction because a functional channel contains 4 TRP subunits, either similar or different ones, to form homo- or heteromers.

[Figure 12]

Figure nr. 12 - The quaternary structure of TRP channels allows homo- or heteromeric configurations.

Left: TRP channel subunit, right: structure of functional TRP channel.

[Representatives of the seven TRP subfamilies]

The seven TRP subfamilies. Representatives of the different subfamilies are indicated at the top and bottom, respectively. Several domains are indicated: ankyrin repeats (A), coiled coil domain (cc), protein kinase domain (TRPM6/7 only), transmembrane segments, and the TRP domain (1)

TRP proteins are supposed to form 6 membrane-spanning segments whereas the pore region is formed by a hydrophilic region between S5 and S6 forms. The N- and C-termini are located intracellularly. The N-terminus often contains ankyrin repeats as well as a coiled-coil domain, which are suspected to bind with other proteins or the cytoskeleton. Especially they are thought to be needed for TRP protein interaction because a functional channel contains 4 TRP subunits, either similar or different ones, to form homo- or heteromers (4,5).

[Scheme: Quaternary structure of TRP channels]

The quartenary structure of TRP channels allows homo- or heteromeric configurations. Left: TRP channel subunit, right: structure of functional TRP channel


1. Montell, C. (2005) Sci STKE 2005, re3

4. Goel, M., Sinkins, W. G., and Schilling, W. P. (2002) J Biol Chem 277, 48303-48310

5. Hoenderop, J. G., Voets, T., Hoefs, S., Weidema, F., Prenen, J., Nilius, B., and Bindels, R. J. (2003) Embo J 22, 776-785

Anmerkungen

The source is not given. The illustrations are no longer available online.

Sichter
(WiseWoman), Hindemith


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