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Typus
KomplettPlagiat
Bearbeiter
WiseWoman
Gesichtet
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Untersuchte Arbeit:
Seite: 43, Zeilen: 1ff (entire page)
Quelle: Saparov 2007
Seite(n): 1 (online source), Zeilen: -
[Figure 11]

Figure nr. 11 - The seven TRP subfamilies.

Representatives of the different subfamilies are indicated at the top and bottom, respectively. Several domains are indicated: ankyrin repeats (A), coiled coil domain (cc), protein kinase domain (TRPM6/7 only), transmembrane segments, and the TRP domain.


TRP proteins are supposed to form 6 membrane-spanning segments whereas the pore region is formed by a hydrophilic region between S5 and S6 forms. The N- and C-termini are located intracellular. The N-terminus often contains ankyrin repeats as well as a coiled-coil domain, which are suspected to bind with other proteins or the cytoskeleton. Especially they are thought to be needed for TRP protein interaction because a functional channel contains 4 TRP subunits, either similar or different ones, to form homo- or heteromers.

[Figure 12]

Figure nr. 12 - The quaternary structure of TRP channels allows homo- or heteromeric configurations.

Left: TRP channel subunit, right: structure of functional TRP channel.

[Representatives of the seven TRP subfamilies]

The seven TRP subfamilies. Representatives of the different subfamilies are indicated at the top and bottom, respectively. Several domains are indicated: ankyrin repeats (A), coiled coil domain (cc), protein kinase domain (TRPM6/7 only), transmembrane segments, and the TRP domain (1)

TRP proteins are supposed to form 6 membrane-spanning segments whereas the pore region is formed by a hydrophilic region between S5 and S6 forms. The N- and C-termini are located intracellularly. The N-terminus often contains ankyrin repeats as well as a coiled-coil domain, which are suspected to bind with other proteins or the cytoskeleton. Especially they are thought to be needed for TRP protein interaction because a functional channel contains 4 TRP subunits, either similar or different ones, to form homo- or heteromers (4,5).

[Scheme: Quaternary structure of TRP channels]

The quartenary structure of TRP channels allows homo- or heteromeric configurations. Left: TRP channel subunit, right: structure of functional TRP channel


1. Montell, C. (2005) Sci STKE 2005, re3

4. Goel, M., Sinkins, W. G., and Schilling, W. P. (2002) J Biol Chem 277, 48303-48310

5. Hoenderop, J. G., Voets, T., Hoefs, S., Weidema, F., Prenen, J., Nilius, B., and Bindels, R. J. (2003) Embo J 22, 776-785

Anmerkungen

The source is not given. The illustrations are no longer available online.

Sichter
(WiseWoman), Hindemith

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