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Arteriogenesis in Gja5 (Connexin-40) deficient mice

von Dr. Haitao Wang

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Statistik und Sichtungsnachweis dieser Seite findet sich am Artikelende
[1.] Haw/Fragment 001 04 - Diskussion
Zuletzt bearbeitet: 2014-10-12 16:26:19 Schumann
Fragment, Gesichtet, Haw, KomplettPlagiat, SMWFragment, Schutzlevel sysop, Van Oostrom et al 2008

Typus
KomplettPlagiat
Bearbeiter
Hindemith
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 1, Zeilen: 4-16
Quelle: Van Oostrom et al 2008
Seite(n): 1379, Zeilen: l. Spalte: 30 ff.
Cardiovascular disorders are currently the leading cause of death globally. Although successful therapies exist to reduce plaque formation and restore blood flow in patients suffering from ischemic vascular diseases, there is still a significant portion of patients who do not benefit from these treatment options. For a long time, it has been known that patients suffering from coronary heart disease can recruit collateral vessels and thereby improve symptoms of myocardial ischemia[1]. Also, it is well established that an increased demand for oxygen, as occurs during exercise and placental development, can induce formation of new capillaries[2]. Thus, it seems that the body already possesses an “in-house” rescue system to increase blood flow in ischemic circumstances. Stimulation of this system, termed neovascularization, could be a promising new direction in treating cardiovascular diseases[3]. Neovascularization in humans can be brought about by three distinct mechanisms: vasculogenesis, angiogenesis, or arteriogenesis (depicted in Fig. 1.1.)[3].

1. Helfant, R.H., P.S. Vokonas, and R. Gorlin, Functional importance of the human coronary collateral circulation. N Engl J Med, 1971. 284(23): p. 1277-81.

2. Prior, B.M., H.T. Yang, and R.L. Terjung, What makes vessels grow with exercise training? J Appl Physiol, 2004. 97(3): p. 1119-28.

3. Carmeliet, P., Mechanisms of angiogenesis and arteriogenesis. Nat Med, 2000. 6(4): p. 389-95.

In fact, cardiovascular disorders are currently the leading cause of death globally [1]. Although successful therapies exist to reduce plaque formation and restore blood flow in patients suffering from ischemic vascular diseases, there is still a significant portion of patients who do not benefit from these treatment options.

For a long time, it has been known that patients suffering from coronary heart disease can recruit collateral vessels and thereby improve symptoms of myocardial ischemia [2]. Also, it is well established that an increased demand in oxygen, as occurs during exercise and placental development, can induce formation of new capillaries [3]. Thus, it seems that the body already possesses an “in-house” rescue system to increase blood flow in ischemic circumstances. Stimulation of this system, termed neovascularization, could be a promising new direction in treating cardiovascular diseases. Neovascularization in humans can be fulfilled by three distinct mechanisms: vasculogenesis, angiogenesis, or arteriogenesis (depicted in Fig. 1) [4].


1. World Health Organization (February 2007) Factsheet 317.

2. Helfant, R. H., Vokonas, P. S., Gorlin, R. (1971) Functional importance of the human coronary collateral circulation. N. Engl. J. Med. 284, 1277–1281.

3. Prior, B. M., Yang, H. T., Terjung, R. L. (2004) What makes vessels grow with exercise training? J. Appl. Physiol. 97, 1119–1128.

4. Carmeliet, P. (2000) Mechanisms of angiogenesis and arteriogenesis. Nat. Med. 6, 389–395.

Anmerkungen

Ein Verweis auf die Quelle fehlt.

Sichter
(Hindemith), SleepyHollow02

[2.] Haw/Fragment 001 17 - Diskussion
Zuletzt bearbeitet: 2014-10-15 18:54:25 Singulus
Fragment, Gesichtet, Haw, KomplettPlagiat, Limbourg et al 2009, SMWFragment, Schutzlevel sysop

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Hindemith
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Untersuchte Arbeit:
Seite: 1, Zeilen: 17-23
Quelle: Limbourg et al 2009
Seite(n): 1737, Zeilen: l. Spalte: 6ff
During embryonic development, blood vessels form de novo from angiogenic blood islands in a process termed vasculogenesis. This primary plexus extends by capillary sprouting and eventually remodels into a highly organized network of capillaries, arteries and veins[4]. The postnatal vascular system is critical for maintaining homeostasis and adapts readily to environmental cues and physiological or pathological conditions[5]. This adaptation comprises two different and characteristic responses, angiogenesis and arteriogenesis.

4. Adams, R.H. and K. Alitalo, Molecular regulation of angiogenesis and lymphangiogenesis. Nat Rev Mol Cell Biol, 2007. 8(6): p. 464-78.

5. Carmeliet, P., Angiogenesis in health and disease. Nat Med, 2003. 9(6): p. 653-60.

During the embryonic development, blood vessels form de novo from angiogenic blood islands in a process termed vasculogenesis. This primary plexus extends by capillary sprouting and eventually remodels into a highly organized network of capillaries, arteries and veins2. The postnatal vascular system is critical for maintaining homeostasis and adapts readily to environmental cues and physiological or pathological conditions3. This adaptation comprises two different and characteristic responses, angiogenesis and arteriogenesis.

2. Adams, R.H. & Alitalo, K. Molecular regulation of angiogenesis and lymphangiogenesis. Nat. Rev. Mol. Cell. Biol. 8, 464–478 (2007).

3. Carmeliet, P. Angiogenesis in health and disease. Nat. Med. 9, 653–660 (2003).

Anmerkungen

Ein Verweis auf die Quelle fehlt.

Sichter
(Hindemith) Klgn

[3.] Haw/Fragment 001 25 - Diskussion
Zuletzt bearbeitet: 2014-10-12 16:27:15 Schumann
Fragment, Gesichtet, Haw, KomplettPlagiat, SMWFragment, Schutzlevel sysop, Van Oostrom et al 2008

Typus
KomplettPlagiat
Bearbeiter
Hindemith
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 1, Zeilen: 25-28
Quelle: Van Oostrom et al 2008
Seite(n): 1380, Zeilen: l. Spalte: 9 ff.
The term “arteriogenesis”—the development of large collateral arteries from pre-existing arteriolar anastomoses—was proposed in 1997 by W. Schaper, R. Chapuli-Munoz, and W. Risau[7] to discriminate between arteriogenesis and true angiogenesis.

7. Ito, W.D., et al., Angiogenesis but not collateral growth is associated with ischemia after femoral artery occlusion. Am J Physiol, 1997. 273(3 Pt 2): p. H1255-65.

The term “arteriogenesis”—the development of large collateral arteries from pre-existing arteriolar anastomoses—was proposed in 1997 by W. Schaper, R. Chapuli-Munoz, and W. Risau [10] to discriminate between arteriogenesis and true angiogenesis.

10. Ito, W. D., Arras, M., Scholz, D., Winkler, B., Htun, P., Schaper, W. (1997) Angiogenesis but not collateral growth is associated with ischemia after femoral artery occlusion. Am. J. Physiol. 273, H1255–H1265.

Anmerkungen

Kein Verweis auf die Quelle

Sichter
(Hindemith), SleepyHollow02


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