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Typus
KomplettPlagiat
Bearbeiter
Hindemith
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 32, Zeilen: 3-10
Quelle: Limbourg et al 2009
Seite(n): 1738, 1739, Zeilen: 1738: r. Spalte: 12ff; 1739: l. Spalte: 1ff
The Doppler signal is linearly proportional to perfusion of the upper 200–300 μm of the skin[131]. Tissue perfusion is quantified in regions of interest (ROI) defined in the limbs relative to the contralateral, non-ligated side and can be displayed as color-coded images[132]. Perfusion measurements obtained from ROIs of thighs are confounded by fur, skin pigmentation and motion artifacts from the abdomen and have been shown not to correlate with limb perfusion[132]. We therefore take LDI measurements from the feet, which correlate with other measures of limb perfusion[18, 133].

18. Scholz, D., et al., Contribution of arteriogenesis and angiogenesis to postocclusive hindlimb perfusion in mice. J Mol Cell Cardiol, 2002. 34(7): p. 775-87.

131. Jakobsson, A. and G.E. Nilsson, Prediction of sampling depth and photon pathlength in laser Doppler flowmetry. Med Biol Eng Comput, 1993. 31(3): p. 301-7.

132. Chalothorn, D., et al., Collateral density, remodeling, and VEGF-A expression differ widely between mouse strains. Physiol Genomics, 2007. 30(2): p. 179-91.

133. Helisch, A., et al., Impact of mouse strain differences in innate hindlimb collateral vasculature. Arterioscler Thromb Vasc Biol, 2006. 26(3): p. 520-6.

The Doppler signal is linearly proportional to perfusion of the upper 200–300 μm of the skin22. Tissue perfusion is quantified in regions of interest (ROI) defined in the limbs relative to the contralateral, non-ligated side and can be displayed as color-coded images23. Perfusion measurements obtained from ROIs of thighs are confounded by fur, skin pigmentation and motion artifacts from the abdomen and have been shown not to correlate with limb perfusion23. We therefore

[Seite 1739]

take LDI measurements from the feet, which correlate with other measures of limb perfusion15,24.


15. Scholz, D. et al. Contribution of arteriogenesis and angiogenesis to postocclusive hindlimb perfusion in mice. J. Mol. Cell. Cardiol. 34, 775–787 (2002).

22. Jakobsson, A. & Nilsson, G.E. Prediction of sampling depth and photon path length in laser Doppler flowmetry. Med. Biol. Eng. Comput. 31, 301–307 (1993).

23. Chalothorn, D., Clayton, J.A., Zhang, H., Pomp, D. & Faber, J.E. Collateral density, remodeling, and VEGF-A expression differ widely between mouse strains. Physiol. Genomics 30, 179–191 (2007).

24. Helisch, A. et al. Impact of mouse strain differences in innate hindlimb collateral vasculature. Arterioscler. Thromb. Vasc. Biol. 26, 520–526 (2006).

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