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[1.] Iam/Fragment 007 12 - Diskussion
Zuletzt bearbeitet: 2014-03-12 20:04:04 Graf Isolan
Fragment, Gesichtet, Iam, Lin et al 2006, SMWFragment, Schutzlevel sysop, Verschleierung

Typus
Verschleierung
Bearbeiter
Hindemith, Graf Isolan
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 7, Zeilen: 12-19
Quelle: Lin et al 2006
Seite(n): 1, Zeilen: right col. 5-15
The chemokine family is divided into four main groups based on their structure and chemotactic activity for specific leukocyte populations: C, CC, CXC and CX3C. The subset of CXC chemokines containing a glycine-leucine-arginine (ELR) motif, which immediately precedes the CXC residues, selectively targets neutrophils. While there are seven ELR+ CXC chemokines in the human genome, only four have been identified in the murine genome: keratinocyte-derived chemokine (KC)/CXCL1, macrophage-inflammatory protein-2 (MIP- 2)/CXCL2, LPS-induced chemokine (LIX)/CXCL5 and CXCL15/lungkine (Bozic et al. 1995;Rossi et al. 1999;Wolpe et al. 1989).

Bozic CR, Kolakowski LF, Jr., Gerard NP, Garcia-Rodriguez C, von Uexkull-Guldenband C, Conklyn MJ, Breslow R, Showell HJ, Gerard C (1995) Expression and biologic characterization of the murine chemokine KC. J Immunol 154:6048-6057

Rossi DL, Hurst SD, Xu Y, Wang W, Menon S, Coffman RL, Zlotnik A (1999) Lungkine, a novel CXC chemokine, specifically expressed by lung bronchoepithelial cells. J Immunol 162:5490-5497

Wolpe SD, Sherry B, Juers D, Davatelis G, Yurt RW, Cerami A (1989) Identification and characterization of macrophage inflammatory protein 2. Proc Natl Acad Sci U S A 86:612-616

The chemokine family is divided into four main groups based on their structure and chemotactic activity for specific leukocyte populations: C, CC, CXC, and CX3C. The subset of CXC chemokines containing a glycine-leucine-arginine (ELR) motif, immediately preceding the CXC residues, selectively target neutrophils. Although there are seven ELR+ CXC chemokines in the human genome, only four have been identified in the murine genome: CXCL1/keratinocyte-derived chemokine (KC)1, CXCL2/MIP-21, CXCL5/LPS-induced chemokine (LIX)1, and CXCL15/lungkine [8–12].

8. Smith, J. B., Herschman, H. R. (1997) Identification of inflammatory mediators by screening for glucocorticoid-attenuated response genes. Methods Enzymol. 287, 250–265.

9. Wolpe, S. D., Sherry, B., Juers, D., Davatelis, G., Yurt, R. W., Cerami, A. (1989) Identification and characterization of macrophage inflammatory protein 2. Proc. Natl. Acad. Sci. USA 86, 612–616.

10. Wuyts, A., Haelens, A., Proost, P., Lenaerts, J. P., Conings, R., Opdenakker, G., Van Damme, J. (1996) Identification of mouse granulocyte chemotactic protein-2 from fibroblasts and epithelial cells. Functional comparison with natural KC and macrophage inflammatory protein-2. J. Immunol. 157, 1736–1743.

11. Rossi, D. L., Hurst, S. D., Xu, Y., Wang, W., Menon, S., Coffman, R. L., Zlotnik, A. (1999) Lungkine, a novel CXC chemokine, specifically expressed by lung bronchoepithelial cells. J. Immunol. 162, 5490–5497.

12. Bozic, C. R., Kolakowski Jr., L. F., Gerard, N. P., Garcia-Rodriguez, C., von Uexkull-Guldenband, C., Conklyn, M. J., Breslow, R., Showell, H. J., Gerard, C. (1995) Expression and biologic characterization of the murine chemokine KC. J. Immunol. 154, 6048–6057.

Anmerkungen

The source is not mentioned.

Sichter
(Hindemith), (Graf Isolan) Schumann

[2.] Iam/Fragment 007 20 - Diskussion
Zuletzt bearbeitet: 2014-03-19 21:11:05 Hindemith
Fragment, Gesichtet, Iam, Moriconi et al 2008, SMWFragment, Schutzlevel sysop, Verschleierung

Typus
Verschleierung
Bearbeiter
Graf Isolan
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 7, Zeilen: 20-26
Quelle: Moriconi et al 2008
Seite(n): 162-163, Zeilen: 162: right col. 39-42 - 163: left col. 1-5
The CXC (or α) chemokines, such as Interleukin-8(IL-8)/CXCL8, CXCL9/MIG, CXCL10/IP10, CXCL11/ITAC and CXCL12/SDF1 have the potential to activate and attract neutrophils and T lymphocytes (Harris et al. 1996) while the C-C (or β) chemokines, such as MCP1/CCL2, MIP-1α/CCL3, MIP-1β/CCL4, MIP-3α/CCL20 and MIP-3β/CCL19, are predominantly chemoattractants for multiple leukocyte subtypes, including monocytes, eosinophils, basophils, T lymphocytes, dendritic cells, natural killer (NK) cells and, to a lesser extent, neutrophils (Ajuebor et al. 1998).

Ajuebor MN, Flower RJ, Hannon R, Christie M, Bowers K, Verity A, Perretti M (1998) Endogenous monocyte chemoattractant protein-1 recruits monocytes in the zymosan peritonitis model. J Leukoc Biol 63:108-116

Harris JG, Flower RJ, Watanabe K, Tsurufuji S, Wolitzky BA, Perretti M (1996) Relative contribution of the selectins in the neutrophil recruitment caused by the chemokine cytokine-induced neutrophil chemoattractant (CINC). Biochem Biophys Res Commun 221:692-696

[Page 162]

The C-X-C (or α) chemokines, such as CINC1, IP10, MIG, ITAC and SDF1, have the potential to activate and attract neutrophils and T lymphocytes (18), while the C-C (or β) chemokines, such as

[Page 163]

MCP1, MIP1α, MIP1β, MIP3α and MIP3β, are predominantly chemoattractants for multiple leukocyte subtypes, including monocytes, eosinophils, basophils, T lymphocytes, dendritic cells, natural killer (NK) cells and, to a lesser extent, neutrophils (19).


18. J. G. Harris, R. J. Flower, K. Watanabe, S. Tsurufuji, B. A. Wolitzky and M. Perretti, Relative contribution of the selectins in the neutrophil recruitment caused by the chemokine cytokine-induced neutrophil chemoattractant (CINC). Biochem. Biophys. Res. Commun. 221, 692–696 (1996).

19. M. N. Ajuebor, R. J. Flower, R. Hannon, M. Christie, K. Bowers, A. Verity and M. Perretti, Endogenous monocyte chemoattractant protein-1 recruits monocytes in the zymosan peritonitis model. J. Leukoc. Biol. 63, 108–116 (1998).

Anmerkungen

Nothing is marked as a citation.

Note: Ajuebor et al. (1998) does not contain the parallel text.

Sichter
(Graf Isolan), Hindemith


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