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Typus
KomplettPlagiat
Bearbeiter
Singulus
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 3, Zeilen: 27-32
Quelle: Quesaraku et al. 2009
Seite(n): 910, Zeilen: r. col. 4ff.
The efficacy of this therapy is limited, among other things, by the fact that it cannot be delivered without hitting normal, healthy tissue surrounding the tumour, with radiation-induced acute and chronic side effects. Radiation is known to induce DNA damage and chromosomal instability of cells both from tumorous and normal tissue (Sakata et al. 2007). However, beyond this, there are further [mechanisms involved in the actions occurring after the exposure of cells and tissue to ionizing radiation, such as radiation-induced apoptosis (Hasegawa et al. 2002).]

Sakata K, Someya M, Matsumoto Y, Hareyama M (2007) Ability to repair DNA double-strand breaks related to cancer susceptibility and radiosensitivity. Radiat Med 25:433-438

[Hasegawa M, Imai R, Nojima K, Sakurai H, Suzuki Y, Kawashima M, Matsuura M, Nakamura Y, Nakano T (2002) [Radiation-induced apoptosis in vivo: therapeutic significance of apoptosis in radiation therapy]. Nippon Igaku Hoshasen Gakkai Zasshi 62:535-539]

The efficacy of this therapy is limited, among other things, by the fact that it cannot be delivered without hitting normal, healthy tissue surrounding the tumour, with radiation-induced acute and chronic side effects. Radiation is known to induce DNA damage and chromosomal instability of cells both from tumorous and normal tissue (24). However, beyond this, there are further mechanisms involved in the actions occurring after the exposure of cells and tissue to ionizing radiation, such as radiation-induced apoptosis (25) and radiation-induced changes in gene expression (26–28).

24. Sakata K, Someya M,Matsumoto Y, Hareyama M. Ability to repair DNA double-strand breaks related to cancer susceptibility and radiosensitivity. Radiat Med 2007; 25: 433–8.

25. Hasegawa M, Imai R, Nojima K, et al. Radiation-induced apoptosis in vivo: therapeutic significance of apoptosis in radiation therapy. Nippon Igaku Hoshasen Gakkai Zasshi 2002; 62: 535–9.

26. Christiansen H, Batusic D, Saile B, et al. Identification of genes responsive to gamma radiation in rat hepatocytes and rat liver by cDNA array gene expression analysis. Radiat Res 2006; 165: 318–25.

27. Christiansen H, Sheikh N, Saile B, et al. X-irradiation in rat liver: consequent upregulation of hepcidin and downregulation of hemojuvelin and ferroportin-1 gene expression. Radiology 2007; 242: 189–97.

28. Moriconi F, Christiansen H, Raddatz D, et al. Effect of radiation on gene expression of rat liver chemokines: in vivo and in vitro studies. Radiat Res 2008; 169: 162–9.

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(Singulus), Graf Isolan

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