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| Untersuchte Arbeit: Seite: 7, Zeilen: 12-19 |
Quelle: Lin et al 2006 Seite(n): 1, Zeilen: right col. 5-15 |
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| The chemokine family is divided into four main groups based on their structure and chemotactic activity for specific leukocyte populations: C, CC, CXC and CX3C. The subset of CXC chemokines containing a glycine-leucine-arginine (ELR) motif, which immediately precedes the CXC residues, selectively targets neutrophils. While there are seven ELR+ CXC chemokines in the human genome, only four have been identified in the murine genome: keratinocyte-derived chemokine (KC)/CXCL1, macrophage-inflammatory protein-2 (MIP- 2)/CXCL2, LPS-induced chemokine (LIX)/CXCL5 and CXCL15/lungkine (Bozic et al. 1995;Rossi et al. 1999;Wolpe et al. 1989).
Bozic CR, Kolakowski LF, Jr., Gerard NP, Garcia-Rodriguez C, von Uexkull-Guldenband C, Conklyn MJ, Breslow R, Showell HJ, Gerard C (1995) Expression and biologic characterization of the murine chemokine KC. J Immunol 154:6048-6057 Rossi DL, Hurst SD, Xu Y, Wang W, Menon S, Coffman RL, Zlotnik A (1999) Lungkine, a novel CXC chemokine, specifically expressed by lung bronchoepithelial cells. J Immunol 162:5490-5497 Wolpe SD, Sherry B, Juers D, Davatelis G, Yurt RW, Cerami A (1989) Identification and characterization of macrophage inflammatory protein 2. Proc Natl Acad Sci U S A 86:612-616 |
The chemokine family is divided into four main groups based on their structure and chemotactic activity for specific leukocyte populations: C, CC, CXC, and CX3C. The subset of CXC chemokines containing a glycine-leucine-arginine (ELR) motif, immediately preceding the CXC residues, selectively target neutrophils. Although there are seven ELR+ CXC chemokines in the human genome, only four have been identified in the murine genome: CXCL1/keratinocyte-derived chemokine (KC)1, CXCL2/MIP-21, CXCL5/LPS-induced chemokine (LIX)1, and CXCL15/lungkine [8–12].
8. Smith, J. B., Herschman, H. R. (1997) Identification of inflammatory mediators by screening for glucocorticoid-attenuated response genes. Methods Enzymol. 287, 250–265. 9. Wolpe, S. D., Sherry, B., Juers, D., Davatelis, G., Yurt, R. W., Cerami, A. (1989) Identification and characterization of macrophage inflammatory protein 2. Proc. Natl. Acad. Sci. USA 86, 612–616. 10. Wuyts, A., Haelens, A., Proost, P., Lenaerts, J. P., Conings, R., Opdenakker, G., Van Damme, J. (1996) Identification of mouse granulocyte chemotactic protein-2 from fibroblasts and epithelial cells. Functional comparison with natural KC and macrophage inflammatory protein-2. J. Immunol. 157, 1736–1743. 11. Rossi, D. L., Hurst, S. D., Xu, Y., Wang, W., Menon, S., Coffman, R. L., Zlotnik, A. (1999) Lungkine, a novel CXC chemokine, specifically expressed by lung bronchoepithelial cells. J. Immunol. 162, 5490–5497. 12. Bozic, C. R., Kolakowski Jr., L. F., Gerard, N. P., Garcia-Rodriguez, C., von Uexkull-Guldenband, C., Conklyn, M. J., Breslow, R., Showell, H. J., Gerard, C. (1995) Expression and biologic characterization of the murine chemokine KC. J. Immunol. 154, 6048–6057. |
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