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Typus
KomplettPlagiat
Bearbeiter
Graf Isolan
Gesichtet
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Untersuchte Arbeit:
Seite: 11, Zeilen: 5-12
Quelle: Moriconi et al 2008
Seite(n): 162, Zeilen: right col. 3-12
The response of hepatocytes to radiation is heterogeneous and is dependent on oxygen concentration. However, in general, hepatocytes are considered more radioresistant than other cells (Alati et al. 1989b;Alati et al. 1989a). In contrast, the liver is a radiosensitive organ. The threshold dose for injury after whole-liver irradiation has been reported to be between 20 and 30 Gy (Anscher et al. 1990). In animal studies, liver irradiation above a threshold dose is not followed by a recovery phase and a complete return to normal. Instead, progressive liver fibrosis and cirrhosis may occur (Geraci et al. 1993).

Alati T, Eckl P, Jirtle RL (1989a) An in vitro micronucleus assay for determining the radiosensitivity of hepatocytes. Radiat Res 119:562-568

Alati T, Van CM, Jirtle RL (1989b) Radiosensitivity of parenchymal hepatocytes as a function of oxygen concentration. Radiat Res 118:488-501

Anscher MS, Crocker IR, Jirtle RL (1990) Transforming growth factor-beta 1 expression in irradiated liver. Radiat Res 122:77-85

Geraci JP, Mariano MS (1993) Radiation hepatology of the rat: parenchymal and nonparenchymal cell injury. Radiat Res 136:205-213

Geraci JP, Mariano MS, Jackson KL (1993) Radiation hepatology of the rat: time-dependent recovery. Radiat Res 136:214-221

The response of hepatocytes to radiation is heterogeneous and is dependent on oxygen concentration (4). However, in general, hepatocytes are considered more radioresistant than other cells (5–10). In contrast, the liver is a radiosensitive organ. The threshold dose for injury after whole-liver irradiation has been reported to be between 20 and 30 Gy (11). In animal studies, liver irradiation above a threshold dose is not followed by a recovery phase and a complete return to normal. Instead, progressive liver fibrosis and cirrhosis may occur (12).

4. T. Alati, M. Van Cleeff and R. L. Jirtle, Radiosensitivity of parenchymal hepatocytes as a function of oxygen concentration. Radiat. Res. 118, 488–501 (1989).

5. T. Alati, P. Eckl and R. L. Jirtle, An in vitro micronucleus assay for determining the radiosensitivity of hepatocytes. Radiat. Res. 119, 562–568 (1989).

6. T. Alati, M. Van Cleeff, S. C. Strom and R. L. Jirtle, Radiation sensitivity of adult human parenchymal hepatocytes. Radiat. Res. 115, 152–160 (1988).

7. R. L. Jirtle, G. Michalopoulos, J. R. McLain and J. Crowley, Transplantation system for determining the clonogenic survival of parenchymal hepatocytes exposed to ionizing radiation. Cancer Res. 41, 3512–3518 (1981).

8. R. L. Jirtle, J. R. McLain, S. C. Strom and G. Michalopoulos, Repair of radiation damage in noncycling parenchymal hepatocytes. Br. J. Radiol. 55, 847–851 (1982).

9. R. L. Jirtle, G. Michalopoulos, S. C. Strom, P. M. DeLuca and M. N. Gould, The survival of parenchymal hepatocytes irradiated with low and high LET radiation. Br. J. Cancer 6, 197–201 (1984).

10. R. L. Jirtle, P. M. DeLuca, W. M. Hinshaw and M. N. Gould, Survival of parenchymal hepatocytes irradiated with 14.3 MeV neutrons. Int. J. Radiat. Oncol. Biol. Phys. 10, 895–899 (1984).

11. R. L. Jirtle, M. S. Anscher and T. Alati, Radiation sensitivity of the liver. Adv. Radiat. Biol. 14, 269–311 (1990).

12. J. P. Geraci, M. S. Mariano and K. L. Jackson, Radiation hepatology of the rat: Time-dependent recovery. Radiat. Res. 136, 214–221 (1993).

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Sichter
(Graf Isolan), Hindemith

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