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Typus
Verschleierung
Bearbeiter
Hindemith
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 24, Zeilen: 4-18
Quelle: Christiansen et al 2007
Seite(n): 190, 191, Zeilen: 190: col 3: 18-33 - 191: col 1: 1-20
The in-vivo experiments were performed as described previously: (Christiansen et al. 2006). Before irradiation planning computed tomography (CT) was performed with a scanner (Somatom Balance; Siemens Medical Solutions, Erlangen, Germany) in each rat to delineate the livers of the animals. The rats were anaesthetized intraperitoneally (IP) with 90 mg ketamine per kilogram of body weight (Intervet, Unterschleissheim, Germany) and 7.5 mg/kg of 2% xylazine (Serumwerk Bernburg, Bernburg/Saale, Germany). The margins of the liver were marked on the skin of the animals and a dose distribution was calculated. The livers were irradiated selectively with 6–MeV photons (dose rate, 2.4 Gy/min) by using an accelerator (Clinac 600 C; Varian, Palo Alto, Calif). A dose of 25 Gy in a single treatment was delivered by using an anteroposterior and posteroanterior treatment technique. Normal sham-irradiated animals, which were transported and anesthetized simultaneously with the irradiated animals, served as specific controls. Animals were observed at specified times up to 48 hours after irradiation and seemed to behave normally without signs of discomfort. Livers and serum samples were taken from five animals each at 1, 3, 6, 12, 24, and 48 hours after irradiation and frozen.

Christiansen H, Batusic D, Saile B, Hermann RM, Dudas J, Rave-Frank M, Hess CF, Schmidberger H, Ramadori G (2006) Identification of genes responsive to gamma radiation in rat hepatocytes and rat liver by cDNA array gene expression analysis. Radiat Res 165:318-325

[page 190]

In vivo experiments were performed by several authors (H.C., F.R., M.R., R.M.H., A.H.) in consensus, as described previously by Christiansen et al (31): Planning computed tomography (CT) was performed with a scanner (Somatom Balance; Siemens Medical Solutions, Erlangen, Germany) in each rat to delineate the livers of the animals. The rats were intraperitoneally anesthetized with 90 mg per kilogram of body weight of ketamine (Intervet, Unterschleissheim, Germany) and 7.5 mg/kg of 2% xylazine (Serumwerk Bernburg, Bernburg/Saale, Germany). The margins of the liver were marked

[page 191]

on the skin of each animal, and a dose distribution was calculated.

The livers were irradiated selectively with 6–MeV photons (dose rate, 2.4 Gy/min) by using an accelerator (Clinac 600 C; Varian, Palo Alto, Calif). A dose of 25 Gy in a single treatment was delivered by using an anteroposterior and posteroanterior treatment technique. Normal sham-irradiated animals, which were transported and anesthetized simultaneously with the irradiated animals, served as specific controls. Animals were observed at specified times up to 48 hours after irradiation and seemed to behave normally without signs of discomfort. Livers and serum samples were taken from five animals each at 1, 3, 6, 12, 24, and 48 hours after irradiation and frozen.


31. Christiansen H, Batusic D, Saile B, et al. Identification of genes responsive to gamma radiation in rat hepatocytes and rat liver by cDNA array gene expression analysis. Radiat Res 2006;165:318–325.

Anmerkungen

Christiansen et al. (2006) does not have the passage in this formulation.

It is not surprising that the same research group follows a similar or the same protocol for different experiments. However, text re-use should be clearly marked and the correct source given.

Sichter
(Hindemith) Schumann

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