Reconsolidation: Behavioural and Electrophysiological Sequelae of Context and Stress in Human Episodic Memory
von Dr. Jennifer L. Moore
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| [1.] Jm/Fragment 099 03 - Diskussion Zuletzt bearbeitet: 2014-02-18 20:49:30 Hindemith | Fragment, Gesichtet, Jm, NUI Galway 2006, SMWFragment, Schutzlevel sysop, Verschleierung |
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| Untersuchte Arbeit: Seite: 99, Zeilen: 3-7, 9-11, 12-17, 20-21 |
Quelle: NUI Galway 2006 Seite(n): 1, Zeilen: 21-35, 38-40 |
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| Unstimulated (i.e., presumably unaffected by stressors or other factors – ‘normal’/baseline level) cortisol follows a diurnal rhythm that is dictated by the sleep-wake cycle, rather than a light-dark cycle: there is a typical and consistent flood of cortisol in the body upon awakening, generally declining thereafter, and cortisol secretion follows a series of peaks and troughs throughout the day, [with a small peak associated with a lunch-time meal (Preussner et al., 1997, in Pollard & Ice, 2007; Kirschbaum & Hellhammer, 2000),] which tends to taper off to a more steady, less steep decline in the afternoon. It is for this reason that laboratory studies examining cortisol generally schedule post-noon testing sessions. [Therefore, all participants were scheduled to commence the session at 3pm in the current study (see Appendix 14).] Variations in this cycle are seen in clinical populations – for instance, a blunted response has been demonstrated in individuals with depression and those experiencing socioeconomic hardship, while extremely elevated, or again, blunted cortisol release can result from a variety of medical conditions. Cortisol secretion can be affected by everyday factors such as consumption of food or beverages prior to sampling, or disrupted sleep patterns. [As a result, stringent guidelines were set forth to control for these factors, and various control measures were distributed (see above) to screen for possible psychopathologies (see Appendices 10 and 11).]
Cortisol in saliva is a particularly robust biologically-active compound, and samples remain viable for several days at room temperature, as well as when frozen and refrozen. |
Unstimulated (i.e., presumably unaffected by stressors or other factors – ‘normal’/baseline level) cortisol follows a diurnal rhythm that is dictated by the sleep-wake cycle, rather than a light-dark cycle: there is a typical and consistent flood of cortisol in the body upon awakening, generally declining thereafter, and cortisol secretion follows a series of peaks and troughs throughout the day, which tend to taper off to a more steady, less steep decline in the afternoon. It is for this reason that laboratory studies examining cortisol usually schedule post-noon testing sessions. Variations in this cycle are seen in clinical populations – for instance, a blunted response has been demonstrated in individuals with depression and those experiencing socioeconomic hardship, while extremely elevated, or again, blunted cortisol release can result from a variety of medical conditions. Cortisol secretion can be affected by everyday factors such as consumption of food or beverages prior to sampling, or disrupted sleep patterns. [Clinically, hyper-secretion of cortisol can lead to the development of Cushing’s disease. while hypo-secretion can result in Addison’s disease.]
Cortisol in saliva is a particularly robust biologically-active compound, and samples remain viable for several days at room temperature, as well as when frozen and refrozen. |
No source is given. |
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